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Chronic Lymphocytic Leukemia

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Prognosis of Chronic Lymphocytic Leukemia

The prognosis of Chronic Lymphocytic Leukemia (CLL) is rather mixed. Most patients will live for 5 to 10 years. However, some die within 2-3 years of diagnosis.

In most patients, the disease begins in a benign way followed by a progressive and resistant terminal phase that lasts for 1-2 years. During the latter phase morbidity is high, both due to the disease itself and from the complications that are caused by the therapy.

The prognosis of Chronic Lymphocytic Leukemia may be influenced by -

 The duration of CLL

 Stage of the disease

 Complications that may arise and their outcome

 Chances for recovery and the time taken to recover

 Recurrence of the disease

 General health condition of the patient

The median life–expectancy of patients is as follows-

 Low-risk group: 14+ years

 Intermediate risk group: 8 years

 High–risk group: 4 years

Some of the CLL indicators and their impact on prognosis is given below-
SNo. INDICATOR PROGNOSTIC IMPLICATIONS
1 <1 yr lymphocyte doubling time Advanced
2 Hb level
  <100g/l in women and <110g/l in men
 
Advanced
3 Bone marrow histology:
  -Diffuse
  -Non-diffuse
 
Advanced
Better prognosis
4 Enzyme Zap-70 Advanced
5 Beta2microglobulin
  <2.0mg/l
  >2.0mg/l
 
Better prognosis
Advanced
6 IgVH genes
  -Mutated
  -Unmutated
 
Better prognosis
Poor prognosis
7 Elevated Lactate Dehydrogenase levels Poor prognosis
8 CD38 expression
  <30%
  >30%
 
Better prognosis
Poor prognosis
9 Increased CD23 in blood Advanced state
10 Chromosomal abnormalities like
  11qdel,17p del and p53 gene del
 
Poor prognosis

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My dad has been just diagnosed with cll. He is 65 yrs old, a smoker for about 50yrs. now. He said he has not felt right for about 4-5yrs. said he knew something was wrong. His white blood cell count is 280,000 and still fighting shingles. What is his prognosis?
jen71 Wednesday, July 04, 2012
I'm 48 years old and have had 7 heart attacks in the last 14 years along with 12 stents. Recently I was diagnosed with stage 4 CLL. Can you give me any ideas on life expectancy?
dazedandconfused Monday, April 23, 2012
my mother is diagnosed with CLL, 63 is the count of platelets and 112400 of wbc what are te chances
saba_mother Tuesday, July 20, 2010
Is CLL hereditary?
wanda Tuesday, September 15, 2009
Yes, my doctor told me it was. I have CLL and my brother and sister has it.
John66 Friday, January 11, 2013
I WANT TO START AND LEAD SUPPORT GROUP IN MY AREA- DWIGHT ILLINOIS FOR THOSE DIAGNOSED WITH BLOOD CANCERS- I HAVE CLL
svanecek Tuesday, April 21, 2009
I have CLL with itching (pruritus), which was extremely severe at onset, but continued at a lower level after chemo therapy. Antihistamines are totally useless in treating it. Does anyone else have this complication, and if so, had a treatment that controlled it? Thanks.
shergald Wednesday, March 25, 2009
I am in W and W and am really suffering from pruritus [itching]. I've seen a many specialist (derm, chiro, allergist, family physician, accupunture, etc.) and no one is able to relieve it. I scratch myself raw -

I am anxious for treatment just for some relief from this.

guest Wednesday, January 13, 2010
I have HIVES every month, for last 3 years, documented occurance for 2 years, blood test revealed CLL...But Onc states has nothing to do with IT. On Rituxan for last year, hives have decreased in quanity, intensity . Will be stoppin g Rituxan in two months and scared..use of Epipen, Ativan and IM Bendryl. Hospital ER visits via ambulance several times and costly, for I can manage this at home, due to experience and many times dealing with.
donnawhite Wednesday, February 27, 2013

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