Immune System may be Used to Reduce Prostate Cancer Risk

by Rajashri on  September 27, 2009 at 4:11 PM Cancer News
RSS Email Print This Page Comment
Font : A-A+

 Immune System may be Used to Reduce Prostate Cancer Risk
A novel way to reduce the genetic risk of prostate cancer has been identified by researchers from the University of Michigan Comprehensive Cancer Centre.

Typically, vaccines are based on specific antigens and trigger immunity for a specific pathogen.

It is challenging for cancer as the best lymphocytes that generate immunity to cancer are eliminated during development.

The researchers have revealed that rescuing these critical immune system cells can help reduce genetic risk of prostate cancer.

They sought to rescue key lymphocytes - called high affinity cancer-reactive T cells - during their development.

During the study, researchers showed that T cells involved in prostate cancer are deleted because of a gene called lymphotoxin alpha.

When the mice lacked lymphotoxin, these T cells came back. These mice become more resistant to prostate cancer. This result suggests that lymphotoxin can be a good target for immune prevention.

The researchers injected a protein targeting lymphotoxin into cancer-susceptible mice.

Without treatment, all of these mice will develop prostate cancer, and typically by age 6 months half of them will have metastatic cancer that has spread to distant organs. Although the treated mice still developed tumours, none developed metastases after 30 weeks.

"It appears that the rescued T cells delay tumour formation. It may not be that this approach can prevent cancer altogether, but it can delay the process and slow the aggressive growth and spread of cancer," said study author Dr Pan Zheng, associate professor of surgery and pathology at the U-M Medical School.

"There is a certain population with a high likelihood of getting cancer, and we need better strategies to minimize their risk.

This approach may be translated into clinical care for those patients," Zheng added.

Source: ANI
RAS

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Would this treatment be of value for slowing the progression of pre-existing prostate cancer?

More News on:

Prostate Cancer Cancer and Homeopathy Immunisation Trans-Urethral Resection of the Prostate Prostate Cancer Facts Cancer Facts Cancer Tattoos A Body Art Hematuria Prostate Cancer: Treatment Options 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive