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Goserelin

Latest prescription information about Goserelin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Goserelin
Pronunciation : GOE-se-rel-in
Trade Name(s): 
International- Zoladex Inj, Zoladex La Vial.
Why it is prescribed (Indications) : 
This medication is a synthetic analogue of gonadotropin-releasing hormone (GnRH) agonist, used to suppress production of the sex hormones (testosterone and estrogen), prescribed for the treatment of endometriosis, breast and prostate cancer.

When it is not to be taken (Contraindications): 


Contraindicated in women who are or may become pregnant and breastfeeding; patients with known hypersensitivity.

Pregnancy Category :

A B C D X
Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.


When it is to be taken : 
Palliative treatment of prostate cancer: Adult- 3.6 mg injected into the anterior abdominal wall every 28 days or 10.8 mg every 12 weeks. An anti-androgen is given several days before beginning of the treatment and continued for at least 3 weeks to prevent disease flare.
How it should be taken : 
Implant placed by your doctor or nurse in a hospital.
Special Instruction : 
*It may cause urinary tract obstruction, spinal cord compression, and decreases bone density in women.
*Women should take contraceptives.
*Monitor blood sugar regularly, it may affect blood sugar.
*Monitor men at tumor risk.
*Caution should be exercised in patients with history of urinary problems, spinal cord problems, mental illness, diabetes, heart problems, blood vessel problems, stroke, high blood calcium levels, obesity, any allergy, and who are taking other medications.
Side Effects : 
Genitourinary- Vaginal bleeding and dryness, increase in menstrual bleeding, hot flushes, sexual dysfunction and breast swelling/tenderness.
Central Nervous System- Headache, emotional lability, depression, sleeplessness, dizziness and tingling.
Miscellaneous-
Joint pain, sweating and injection site reactions.
Other Precautions : 
*Monitor bone mineral density regularly.
Storage Conditions : 
Injection: Store below 25°C.Store it at room temperature and keep away from children.

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