General Info about Leukemia
Leukemia - which literally means "white blood" in Greek - occurs when there is an excess of abnormal white blood cells in the blood. This is a cancer of the blood cells. This is a term to refer to a group cancerous disorders of blood forming tissues.
Normally blood is made up of fluid and different type of cells called red cells (they carry oxygen and carbon-dioxide), white cells (they fight infection) and platelets (these help in clotting of blood or stopping bleeding on cut wounds). The blood is made in the bone marrow, which is located inside the bones.
Cancer is a group of more than 100 diseases that have two important things in common. One is that certain cells in the body become abnormal. Another is that the body keeps producing large numbers of these abnormal cells.
Leukemia's are either acute or chronic, and are classified by the type of abnormal white blood cell present. Acute cases generally develop more rapidly than chronic cases. If acute leukemia goes untreated it can be fatal within a few weeks or months. However with treatment, life can be prolonged and in some instances a complete cure may be provided. Approximately 6-7 new cases of acute leukemia are diagnosed per 100,000 people in a year.
What is New in Leukemia?
Using RNA epigenetics and chromatin structures as diagnostic tools can help predict and reduce drug resistance in treating patients with leukemia. Drug resistance is a major obstacle to effective treatment for patients with cancer and leukemia. Epigenetic modifying drugs have been proven effective for some patients with hematologic malignancies, such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
Latest Publications and Research on Leukemia
- Clonal hematopoiesis in hematological disorders. - Published by PubMed
- [The impact of KIT and other concomitant gene mutations on the prognoses of patients with core-binding factor acute myeloid leukemia]. - Published by PubMed
- Tumor-stroma interaction increases CD147 expression in neoplastic B lymphocytes in chronic lymphocytic leukemia. - Published by PubMed
- Grape seed proanthocyanidin extract reverses multidrug resistance in HL-60/ADR cells via inhibition of the PI3K/Akt signaling pathway. - Published by PubMed
- Outcome And Clinico-Phenotypical Features Of Acute Lymphoblastic Leukemia/Lymphoma With Cutaneous Involvement: A Multicentric Case-Series. - Published by PubMed