Chemotherapeutic agents or drugs are 'magic bullets' that destroy the fast-dividing cancer cells. However these drugs are unable to differentiate between the normal cells and the cancer cells and they destroy the former too, in their war against cancer. This leads to certain side effects.
Chemotherapy is used in over half the patients who are treated with cancer. It is used to treat not only the cancer cells in an organ but also to treat distant sites to which the tumor or cancer might have spread. Hence chemotherapy is a systemic therapy, meaning, it treats the body as a whole.
When Chemotherapy was first put into practice there were many side effects and sometimes they proved to be fatal. Now the practice is much safer with better monitoring and the usage of combination therapy. When an oncologist prescribes a chemotherapy regimen, they give a combination of drugs to treat the cancer. Some of these drugs are administered to treat the dividing cells at various stages. The regimen may also include some supportive drugs to minimize the side effects. To get the best results it is important to follow the regimen and the schedule.
In the earlier days, when popping an aspirin for a headache was also referred to as chemotherapy, the word was used in reference to any drug or medicine employed to treat a disease. The word ‘anti-bacterial chemotherapy’ is used when antibiotics are employed to control a disease. In that sense, syphilis-treating arsenic compounds were the first modern chemotherapeutic agents. This was followed by other antibiotics, like Sulphonamides and Penicillin. In the modern sense it primarily refers to the cytotoxic drugs used in cancer treatment.
Cancerous conditions like Hodgkins lymphoma, non-Hodgkins Lymphoma, certain types of leukemia and testicular tumor are fully cured using these cytotoxic drugs.
Chemotherapy agents have also found use to treat non-cancer conditions like overcoming transplant rejections and to treat autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
Before starting the chemotherapy one needs to check the performance status of the patient. Performance status is usually a score that tells the physician if the patient is fit to undergo chemotherapy or if the dose of the drugs needs to be reduced.
Latest Publications and Research on ChemotherapyUnusual case of solitary perineal subcutaneous metastasis from sigmoid colon cancer. - Published by PubMed
Late recurrence of basaloid carcinoma initially treated as a small cell lung cancer. - Published by PubMed
Complete response of 7 years' duration after chemoradiotherapy followed by gefitinib in a patient with intramedullary spinal cord metastasis from lung adenocarcinoma. - Published by PubMed
Hypersensitivity reactions to carboplatin and cisplatin in non-small cell lung cancer. - Published by PubMed
Hedgehog signaling pathway: the must, the maybe and the unknown. - Published by PubMed