For the first time a study shows that X-ray lasers can be used to generate a complete 3-D model of a protein without any prior knowledge of its structure.
An international team of researchers working at the Department of Energy's (DOE) SLAC National Accelerator Laboratory produced from scratch an accurate model of lysozyme, a well-studied enzyme found in egg whites, using the Linac Coherent Light Source (LCLS) X-ray laser and sophisticated computer analysis tools.
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The experiment proves that X-ray lasers can play a leading role in studying important biomolecules of unknown structure. The special attributes of LCLS, which allow the study of very small crystals, could cement its role in hunting down many important biological structures that have so far remained out of reach because they form crystals too small for analysis with conventional X-ray sources.
"Determining protein structures using X-ray lasers requires averaging a gigantic amount of data to get a sufficiently accurate signal, and people wondered if this really could be done," said Thomas Barends, a staff scientist at the Max Planck Institute for Medical Research in Germany who participated in the research. "Now we have experimental evidence. This really opens the door to new discoveries."
Collaborators from SLAC and Arizona State University also participated in the research, which was published Nov. 24 in Nature.
Source: Eurekalert
Collaborators from SLAC and Arizona State University also participated in the research, which was published Nov. 24 in Nature.
Source: Eurekalert
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Wireless mobile X-ray kits that make use of tablet computers have been deployed by Japanese medics who are treating victims of the Philippines typhoon.
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Reduction in Risk of Common Duct Injury Not Associated With X-ray of Ducts During Gallbladder Surgery
Analysis of a procedure to help prevent common duct injury during gallbladder removal surgery, use of intraoperative cholangiography was not associated with a reduced risk of common duct injury.
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