
Sildenafil, the erectile dysfunction drug sold as Viagra and now under consideration as a treatment for heart failure, affects males and females very differently, reveals a new study.
According to the cardiovascular researchers of Johns Hopkins University, in female mice modeling human heart failure, the benefits of sildenafil ranged from robust to practically nonexistent, depending on the animals' levels of the hormone estrogen.
Lead scientist Eiki Takimoto said that sildenafil generally appears to work well, but only because it targets a different biological process independent of estrogen in males.
The study was published in The Journal of Clinical Investigation.
Source: ANI
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