Sildenafil, the erectile dysfunction drug sold as Viagra and now under consideration as a treatment for heart failure, affects males and females very differently, reveals a new study.

Lead scientist Eiki Takimoto said that sildenafil generally appears to work well, but only because it targets a different biological process independent of estrogen in males.
He said that the research is especially significant because it offers a mechanism to explain how estrogen affects sildenafil's efficacy and its the first time the actual pathway of a hormone's cause and effect on a drug has been mapped out.
The study was published in The Journal of Clinical Investigation.
Source-ANI