About Careers Internship MedBlog Contact us

Study Says Immune Evasion Uncommon in M. Tuberculosis

by Rajshri on May 24, 2010 at 8:43 PM
Font : A-A+

 Study Says Immune Evasion Uncommon in M. Tuberculosis

Scientists at NYU Langone Medical Center have found that "immune evasion", which is common to many viruses, bacteria and parasites, is uncommon to M. tuberculosis where the antigens remain strikingly unchanged and homogenous.

The study suggests that M. tuberculosis antigens do not mutate because they hope to be recognized by the body's immune system- perhaps because the host immune mechanism that leads to the typical lung destruction and cough can contribute to the spread of the disease.


The discovery could change the direction of vaccine research and eventually result in a new focus on different targets of immune response to the bacteria.

"The finding that the tuberculosis bacterium acts completely differently from other pathogens is quite surprising and unexpected. If you get infected with the influenza virus, for example, the body's immune system recognizes it and tends to eliminate it. In tuberculosis, our immune response doesn't get rid of it - it tends to hold on to it for a while - keeping the bacteria under partial control," Nature quoted Dr. Joel Ernst, lead author of the study, as saying.

The study found that instead of "suffering" from being recognized, recognition of tuberculosis antigens actually benefit the bacteria - and it is this recognition that helps the bacteria to be transmitted from person to person.

For the study, scientists used a novel high-throughput DNA sequencing method to analyze the whole genomes of 22 clinical strains of M. tuberculosis from different parts of the world.

They then determined that the number of and type of mutations that occurred in antigens is much lower compared to other regions of the M. tuberculosis genome.

The study was published in Nature Genetics.

Source: ANI


Recommended Readings

Latest Research News

Good Evening Recovery Leads to Better Work Days
A latest research suggests that the quality of a person's post-work recovery in the evening can impact their mood when they resume work the next day.
Link Between Sleep Apnea and Cognitive Decline
Researchers are working on new strategies and solutions for sleep apnea to ward off a range of health risks including cognitive decline.
Softening Stem Cells Enhances Hair Growth Potential
The scientists discovered that when the stem cells in the hair follicle are made softer, they have a higher chance of growing hair.
Potential New Strategy for Ischemic Stroke Discovered
A combinatorial therapy provided promising beneficial results among people with ischemic stroke.
Is Speech Therapy the Answer to Voice Problems in Parkinson's Disease Patients
In Parkinson's disease patients voice disorders are quite common. A new combination therapy had greater effects on the voice.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Study Says Immune Evasion Uncommon in M. Tuberculosis Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests