An association between arthritis drug Celebrex and heart valve calcification has been identified by Vanderbilt University researchers.
W. David Merryman, professor of biomedical engineering, and Ph.D. student Megan Bowler started out by testing celecoxib, the active compound in Celebrex, on valve cells in an effort to see if it could double as an aortic stenosis therapy. It made the problem worse.
J & K Witnessed the First Child Heart Valve Replacement Surgery
Doctors at the Sher-e-Kashmir Institute of Medical Sciences (SKIMS) in Jammu and Kashmir's summer capital Srinagar have carried out the first successful child heart valve replacement surgery.
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‘Dimethyl celecoxib - an inactive form of celecoxib - could potentially slow or stop aortic stenosis. ’
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To confirm their theory about a link between celecoxib and valve calcification, Merryman, who is also a professor of pharmacology, medicine and pediatrics at Vanderbilt, recruited Michael Raddatz, an M.D./Ph.D. student, to analyze more than 8,600 relevant, anonymous patient records from Vanderbilt University Medical Center. Raddatz checked whether there was a link between Celebrex use and aortic valve disease, and, after correcting for other risk factors, discovered that patients who had taken Celebrex had a 20 percent increased prevalence of valve disease.
The team's results appear today, which is National Heart Valve Disease Awareness Day, in the Journal of the American College of Cardiology (JACC): Basic to Translational Science.
![Leaking Heart Valve of 69-year Old Repaired using a Novel Procedure]( "Leaking Heart Valve of 69-year Old Repaired using a Novel Procedure")
Doctors at Fortis Escorts Heart Institute in New Delhi have performed the MitraClip procedure to repair the leaking heart valve of a 69-year-old man, thereby avoiding the need for an open heart surgery.
The 2016 New England Journal of Medicine study that found Celebrex no more damaging than naproxen and ibuprofen only looked at cardiovascular death and nonfatal heart attack or stroke, not valve disease, which affects more than a quarter of the U.S. population older than 65.
"In this study, we're adding a long-term perspective on celecoxib use," said Bowler, who recently earned her Ph.D. "Calcification in the aortic valve can take many years. So if you're at a higher risk for it, you might want to consider taking a different painkiller or rheumatoid arthritis treatment."
Merryman said he intends to keep testing dimethyl celecoxib for its beneficial effects on heart valve health.
Source: Eurekalert
Leaking Heart Valve of 69-year Old Repaired using a Novel Procedure
Doctors at Fortis Escorts Heart Institute in New Delhi have performed the MitraClip procedure to repair the leaking heart valve of a 69-year-old man, thereby avoiding the need for an open heart surgery.
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The 2016 New England Journal of Medicine study that found Celebrex no more damaging than naproxen and ibuprofen only looked at cardiovascular death and nonfatal heart attack or stroke, not valve disease, which affects more than a quarter of the U.S. population older than 65.
"In this study, we're adding a long-term perspective on celecoxib use," said Bowler, who recently earned her Ph.D. "Calcification in the aortic valve can take many years. So if you're at a higher risk for it, you might want to consider taking a different painkiller or rheumatoid arthritis treatment."
Merryman said he intends to keep testing dimethyl celecoxib for its beneficial effects on heart valve health.
Source: Eurekalert
Heart Valve Replacement: 3D Printed Models Help Determine a Perfect Fit
In patients with moderate-to-severe aortic valve blockages, artificial valves have to be implanted into a patient's heart. This 3D printed heart valves can, in turn, help the cardiac surgeons decide which heart valve replacement size will be best suited for the patient.
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 CelecoxibThis medication is a non-steroidal anti-inflammatory drug, prescribed for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, menstrual pain, and other pain. | Advertisement
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