About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Stem Cell Implant Effective Against Parkinson's Symptoms in Test Studies

by Sheela Philomena on April 4, 2015 at 11:02 PM
Font : A-A+

Stem Cell Implant Effective Against Parkinson's Symptoms in Test Studies

In mice, an implant of stem cells treated with an anti-cancer drug shows promising results for Parkinson's treatment. The findings published in the journal Frontiers in Cellular Neuroscience could be an important step toward using the implantation of stem cell-generated neurons as a treatment for Parkinson's disease in humans.

Using a US Food and Drug Administration (FDA)-approved anti-cancer drug, the researchers were able to grow dopamine-producing neurons derived from embryonic stem cells that remained healthy and functional for as long as 15 months after implantation into mice, restoring motor function without forming tumors.

Advertisement

"This simple strategy of shortly exposing pluripotent stem cells to an anti-cancer drug turned the transplant safer, by eliminating the risk of tumor formation", said the leader of the study Stevens Rehen, professor at the Federal University of Rio de Janeiro (UFRJ) in Brazil. Parkinson's, which affects as many as 10 million people in the world, is caused by a depletion of dopamine-producing neurons in the brain.

Several studies have indicated that the transplantation of embryonic stem cells improves motor functions in animal models. However, until now, the procedure was shown to be unsafe because of the risk of tumors upon transplantation.
Advertisement

To address this issue, the researchers for the first time pre-treated undifferentiated mouse embryonic stem cells with mitomycin C, a drug already prescribed to treat cancer. The substance blocks the DNA replication and prevents the cells from multiplying out of control.

The researchers used mice modelled for Parkinson's. Unlike the control group, animals receiving the treated stem cells showed improvement in Parkinson's symptoms and survived until the end of the observation period of 12 weeks post-transplant with no tumors detected.

Four of these mice were monitored for as long as 15 months with no signs of pathology.

Furthermore, the scientists have also shown that treating the stem cells with mitomycin C induced a four-fold increase in the release of dopamine after in vitro differentiation.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Sea Buckthorn
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Varicocele Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Stem Cells Testicle Pain - Symptom Evaluation 

Recommended Reading
Nutritional Management of Parkinsons disease
Parkinson's disease is a brain disorder which leads to many other related effects. Nutrition plays ....
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Quiz on Parkinsonís Disease
Parkinson's disease is a disease of the central nervous system. Here's an interesting quiz to find ....
Quiz on Stem Cells
Scientists believe (and are working hard) to use stem cells in the future to treat a wide range of ....
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem ......
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord ......
Testicle Pain - Symptom Evaluation
A sudden, severe pain in the testis may be due to testicular torsion. Testicles inside the scrotum a...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use