About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Some Body Organs are Susceptible to Cell Death - Study

by Sheela Philomena on January 27, 2011 at 1:06 PM
Font : A-A+

 Some Body Organs are Susceptible to Cell Death - Study

A recent study has explained why some body organs are more susceptible to cell death than others. This finding would eventually lead to advanced treatment or prevention of heart attack or stroke.

The UC Davis team and their collaborators at the National Institutes of Health and Johns Hopkins University report that Bax, a factor known to promote cell death, is also involved in regulating the behavior of mitochondria, the structures that provide energy inside living cells.

Advertisement

Mitochondria constantly split and fuse. The proteins that control the splitting of mitochondria also promotes a process called apoptosis, or programmed cell death.

In contrast, the proteins that control mitochondrial fusion help protect against cell death. Cell death can happen when cells are starved of oxygen, for example during a heart attack or stroke.
Advertisement

Both human and mouse cells have two proteins, called MFN1 and MFN2, which control outer membrane fusion.

Using mitochondria from cells derived from genetically modified "knockout" mice, Suzanne Hoppins and Jodi Nunnari at UC Davis, studied how these two proteins work together and the role specific genes play in that process.

The research team discovered that these proteins combine with themselves or each other to form a tether between two mitochondria, leading to fusion.

Hoppins also found that a soluble form of Bax, a protein that triggers apoptosis, can also stimulate mitochondria to fuse. It acts only through the MFN2/MFN2 combination, she found.

The form of Bax that promotes mitochondrial fusion is different from the type that leads to cell death, Nunnari said. Bax leads to cell death when it inserts itself in the mitochondrial membrane. In its soluble, free-floating form, it causes mitochondria to fuse instead.

MFN1 and MFN2 are found in different amounts in different body organs. MFN2 is more abundant in the brain and heart tissues where cell death can have disastrous consequences.

The paper shows how MFN2 could act to protect the brain or heart from cell death, by using Bax in a different form, Nunnari said.

The research has been published Jan. 21 in the journal Molecular Cell.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment Death Facts Bereavement Healthy Living Autophagy: Self-Repair Mechanism at Cellular Level 

Most Popular on Medindia

Sinopril (2mg) (Lacidipine) Find a Hospital Blood Pressure Calculator Nutam (400mg) (Piracetam) A-Z Drug Brands in India Calculate Ideal Weight for Infants Find a Doctor Blood - Sugar Chart Turmeric Powder - Health Benefits, Uses & Side Effects Loram (2 mg) (Lorazepam)
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Some Body Organs are Susceptible to Cell Death - Study Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests