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Skin Patch Benefits Kids With Milk-induced Eosinophilic Esophagitis

by Colleen Fleiss on May 24, 2019 at 3:25 AM
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Skin Patch Benefits Kids With Milk-induced Eosinophilic Esophagitis

Skin patch was found to show promising results in treating children with a painful, chronic condition called eosinophilic esophagitis (EoE) triggered by milk, stated new study from Children's Hospital of Philadelphia (CHOP).

Among 20 children with EoE who wore Viaskin Milk - a skin patch measuring just over an inch long containing trace amounts of milk protein - nine (47%) saw an improvement in their symptoms and normalization of their biopsies after 11 months.

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The findings were published online this month in the journal Clinical Gastroenterology and Hepatology.

The pilot study followed 20 children aged 4 to 17 with EoE. The patients followed a milk-free diet for nine months, then re-introduced milk into their diet for the next two months. After 11 months, almost half of those wearing the Viaskin Milk patch had fewer EoE symptoms, including less inflammation when they underwent an endoscopy compared to none in the placebo group.
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"This study shows great promise for an immunotherapy that aims to desensitize children to milk," said study leader Jonathan Spergel, MD, PhD, Chief of the Allergy Program at CHOP. "Our next step would be to launch a much larger study to confirm our results. Currently, there's no cure for EoE, so this would be the first strategy to treat the underlying cause of the disease."

EoE is a food-based disease that causes redness, swelling and itching in the esophagus when a patient eats a food that triggers their reaction. Traditional allergy testing is not helpful. Patients may experience nausea, vomiting, or a burning sensation in the throat. If left untreated, the esophagus may narrow due to scarring. Currently, the only ways to manage EoE is to treat the symptoms with off-label topical steroids which may cause growth retardation, or to follow a restrictive diet which may be difficult for patients to follow. Children with EoE often have other allergic disorders like asthma, seasonal allergies or eczema.

Disclosure of Related Financial Interest: Jonathan M. Spergel, MD, PhD, Antonella Cianferoni, MD, PhD, Megan O. Lewis, MSN, RN, CPNP, and Terri Brown-Whitehorn, MD, have consulting agreements and clinical trial grants with DBV Technologies. Jonathan M. Spergel, MD, PhD, has stock equity with DBV Technologies.

The study sponsor (DBV Technologies) had no role in analysis or interpretation of data. They provided the Viaskin Milk Patch. Final study design was done by Jonathan M. Spergel and Antonella Cianferoni.

Source: Eurekalert
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