At the University of California, San Diego, researchers led by bioengineers have generated the most complete genome sequences from single E. coli cells and individual neurons from the human brain.
The breakthrough comes from a new single-cell genome sequencing technique that confines genome amplification to fluid-filled wells with a volume of just 12 nanoliters.
French Researchers Complete Banana Genome Sequence
There may be some hope for bananas after all with French researchers successfully managing to sequence the banana genome.
Advertisement
The study is published in the journal Nature Biotechnology on November 10, 2013.
"Our preliminary data suggest that individual neurons from the same brain have different genetic compositions. This is a relatively new idea, and our approach will enable researchers to look at genomic differences between single cells with much finer detail," said Kun Zhang, a professor in the Department of Bioengineering at the UC San Diego Jacobs School of Engineering and the corresponding author on the paper.
![Wheat Disease' Vulnerability Discovered With Genome Sequence]( "Wheat Disease' Vulnerability Discovered With Genome Sequence")
A new study has identified the genome sequence of a fungal disease which kills cells in the wheat crop and destroys the resistance of the plant to defend itself.
The researchers report that the genome sequences of single cells generated using the new approach exhibited comparatively little "amplification bias," which has been the most significant technological obstacle facing single-cell genome sequencing in the past decade. This bias refers to the fact that the amplification step is uneven, with different regions of a genome being copied different numbers of times. This imbalance complicates many downstream genomic analyses, including assembly of genomes from scratch and identifying DNA content variations among cells from the same individual.
Single-cell Genome Sequencing
Sequencing the genomes of single cells is of great interest to researchers working in many different fields. For example, probing the genetic make-up of individual cells would help researchers identify and understand a wide range of organisms that cannot be easily grown in the lab from the bacteria that live within our digestive tracts and on our skin, to the microscopic organisms that live in ocean water. Single-cell genetic studies are also being used to study cancer cells, stem cells and the human brain, which is made up of cells that increasingly appear to have significant genomic diversity.
Source: Eurekalert
Wheat Disease' Vulnerability Discovered With Genome Sequence
A new study has identified the genome sequence of a fungal disease which kills cells in the wheat crop and destroys the resistance of the plant to defend itself.
Advertisement
The researchers report that the genome sequences of single cells generated using the new approach exhibited comparatively little "amplification bias," which has been the most significant technological obstacle facing single-cell genome sequencing in the past decade. This bias refers to the fact that the amplification step is uneven, with different regions of a genome being copied different numbers of times. This imbalance complicates many downstream genomic analyses, including assembly of genomes from scratch and identifying DNA content variations among cells from the same individual.
Single-cell Genome Sequencing
Sequencing the genomes of single cells is of great interest to researchers working in many different fields. For example, probing the genetic make-up of individual cells would help researchers identify and understand a wide range of organisms that cannot be easily grown in the lab from the bacteria that live within our digestive tracts and on our skin, to the microscopic organisms that live in ocean water. Single-cell genetic studies are also being used to study cancer cells, stem cells and the human brain, which is made up of cells that increasingly appear to have significant genomic diversity.
Source: Eurekalert
Black Death Genome Sequenced
The entire genome of the Black Death has been sequenced by researchers at McMaster University and the University of Tubingen in Germany.
Advertisement
 Chocolate Yummier With New Genome SequenceA variety of gene families that may bring about a higher quality chocolate have been indentified by an international team of scientists. | Advertisement
|
Advertisement
Latest Research News
Diagnosed autistic individuals showed increased premature mortality in the UK, highlighting urgent needs to address associated inequalities.
Study reveals a correlation between hearing impairment and distinct brain region variances, contributing to dementia.
Financial impact of caring for individuals with neurodegenerative disorders reaches hundreds of billions annually in the United States.
Experts emphasize that addressing the skills gap demands immediate attention and innovative solutions, including education, re-training, and significant time investment.
New study unveiled the cells' ability to adapt in responses and potential implications for conditions such as diabetes and cancer.