About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Identify Antibody That can Reduce Food Craving, Expand Calorie Burn

by Rajashri on October 29, 2008 at 3:03 PM
Font : A-A+

 Scientists Identify Antibody That can Reduce Food Craving, Expand Calorie Burn

An antibody that works against the gastric hormone ghrelin has been identified by scientists at The Scripps Research. Ghrelin has been linked to weight gain and fat storage through its metabolic actions.

Research leaders Kim Janda and Eric P. Zorrilla say that their findings point towards a potentially novel treatment for obesity that would interfere directly with the some of the biological mechanisms determining weight.

Advertisement

The researchers observed during the study that the antibody catalyst GHR-11E11 led to a higher metabolic rate in fasting mice, and suppressed feeding following 24-hour food deprivation.

"Our study showed that this novel catalytic ghrelin antibody could specifically seek out and degrade ghrelin," said Janda, who is Ely R. Callaway, Jr. Professor of Chemistry, member of The Skaggs Institute for Chemical Biology, and director, Worm Institute of Research and Medicine (WIRM), at Scripps Research.
Advertisement

"While this antibody lacks a high level of catalytic efficiency, our study clearly demonstrates that even a basal level of catalysis can effectively modulate feeding behavior. These findings not only validate antibody-based therapeutics, but strongly suggest that catalytic anti-ghrelin antibodies might help patients reach and maintain their weight loss goals," Janda added.

Ghrelin is a gastric endocrine hormone produced primarily in the stomach, which encourage eating during periods of calorie restriction. It promotes weight gain and fat storage through its metabolic actions, decreasing the break down of stored fat for energy as well as energy expenditure itself.

The new study suggests the possibility that passive immunopharmacotherapy with the catalytic anti-ghrelin antibody such as GHR-11E11 could decrease the level of serum ghrelin, and modulate energy homeostasis.

"The reason we looked at passive immunopharmacotherapy to treat obesity was because agonist/antagonist types of drugs have been remarkably unsuccessful," Janda said.

"They are effective only while treatment is maintained and when treatment stops, weight returns. For obesity treatments to work, they must affect food intake and energy expenditure or storage-which is what this new catalytic antibody does by degrading ghrelin. Some people have the idea that because ghrelin is an endogenous hormone there might be too many adverse side effects if you eliminate it, but there is new evidence that the body itself produces antibodies against ghrelin," the researcher added.

Since immunoneutralization would occur outside the central nervous system, the researchers believe that their approach might eliminate potential side effects that might occur with blood-brain barrier-penetrating small molecule antagonists.

Given the complex nature of obesity, any antibody-based strategy would most likely be used in combination with other available drugs, and as part of a comprehensive treatment approach that included nutritional, exercise, educational, and psychosocial components, Janda said.

He, however, conceded that more research was needed and, in addition to the development of more effective ghrelin antibodies, scientists needed to better understand issues like the effect of the antibodies over the long-term and their impact on individuals with varying body weights.

The study has been published in the online edition of the journal Proceedings of the National Academy of Sciences (PNAS).

Source: ANI
RAS/SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Black Pepper as Preventive Measure Against Omicron
FODMAP Diet: A Beginner's Guide
Smallpox
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Low Calorie Diet Burns Why Do We Eat - Nutrition Facts Diet Lifestyle and Heart Disease Hunger Fullness and Weight Control Label Lingo on Food Items: Decoded Top Diet Foods that Make you Fat Top Food for Dieters Selenium - Natural Source Better than Supplements 

Recommended Reading
Obesity
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the ......
Eating Fast Makes You Super-sized
People who gobble down their food and eat until they feel full are three times more likely to get .....
Genetic Predilection may Cause Lifestyle Changes
A team of American scientists has undertaken a new research project to find out how people will ......
Burns
Burn injuries have reached epidemic proportions in recent years. Burn accident statistics show that ...
Hunger Fullness and Weight Control
An erratic way of eating or any metabolic disturbance in the hunger fullness signals is one of the m...
Label Lingo on Food Items: Decoded
Read on to become a “pro” in “label reading” and don’t get tricked by fancy promotions of food produ...
Low Calorie Diet
Low calorie meals or diet include foods that are high on nutritional content and yet have fewer calo...
Selenium - Natural Source Better than Supplements
Selenium is a powerful anti-oxidant that prevents cell damage and helps in thyroid hormone productio...
Top Diet Foods that Make you Fat
Every nutrition fad comes with its share of diet foods. While they seem healthy, many diet foods pro...
Top Food for Dieters
A diet food contains protein, fiber and good fats, which help in weight management. Diet foods if co...
Why Do We Eat - Nutrition Facts
The importance of eating food and the physiological, psychological and social functions of food....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use