Rice, Penn Researchers Develop Transplantation Model for 3-D Printed Constructs

Scientists have created an implant with an intricate network of blood vessels using sugar, silicone and a 3-D printer. According to experts, the technique points toward a future of growing replacement tissues and organs for transplantation. Delivering oxygen and nutrients to all cells in an artificial organ or tissue implant is considered as one of the biggest challenges in regenerative medicine. The research may provide a method to overcome the challenge.

The new study was performed by a research team led by Jordan Miller, assistant professor of bioengineering at Rice University, and Pavan Atluri, assistant professor of surgery at the University of Pennsylvania. The study demonstrated that blood flowed normally through test constructs that were surgically connected to native blood vessels. The report was published in the journal Tissue Engineering Part C: Methods.

Using an open-source 3-D printer that lays down individual filaments of sugar glass one layer at a time, the scientists "printed" a lattice of would-be blood vessel.

“We had a theory that maybe we shouldn’t be waiting,” Miller said. “We wondered if there were a way to implant a 3-D printed construct where we could connect host arteries directly to the construct and get perfusion immediately. In this study, we are taking the first step toward applying an analogy from transplant surgery to 3-D printed constructs we make in the lab.”

The research team thought long-term about what the needs would be for transplantation of large tissues made in the laboratory. “What a surgeon needs in order to do transplant surgery isn’t just a mass of cells; the surgeon needs a vessel inlet and an outlet that can be directly connected to arteries and veins,” he said.



Source-Medindia