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'Human Lego' Could Pave Way for Artificial Organs

by VR Sreeraman on May 24, 2010 at 12:42 PM
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 'Human Lego' Could Pave Way for Artificial Organs

Hope to build artificial organs for human implantation has been boosted with the creation of Lego-like blocks made of human cells.

Javier Fernandez and Ali Khademhosseini at the Massachusetts Institute of Technology have built a variety of living 3D shapes on a cell-by-cell basis, such as tubes and solid spheres.

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Now, the experts anticipate constructing artificial tissues for human implantation with these blocks, reports New Scientist.

The researchers built the "human Lego" by dipping cells cultured from liver tumours into a polymer called polyethylene glycol (PEG).

The parcel was then hardened, or baked, with UV light to form bricks. Another coating of PEG made the bricks sticky, and they were placed in a mold. To fill any gaps, the whole structure was dunked in PEG a final time and irradiated once more.
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Fernandez said, despite being trapped and baked within a polymer, cell staining shows that the cultured cells remained alive.

Earlier attempts to produce 3D cellular structures had failed because cells didn't stick to each other, says Fernandez. PEG overcomes this problem.

However, Emmanuel Reynaud of University College Dublin in Ireland, pointed out polymer is not a tissue. He explained that the individual live cells are not communicating in this experiment, and "cells in a tissue have to communicate with each other".

The study has been published in Advanced Materials.

Source: ANI
SRM
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