About Careers Internship MedBlog Contact us

Vaginal Gel That Could Protect From HIV Developed

by VR Sreeraman on May 24, 2010 at 1:13 PM
Font : A-A+

 Vaginal Gel That Could Protect From HIV Developed

In a test on monkeys, a vaginal microbicide based on a new type of anti-HIV drug could offer significant protection against infection with a virus similar to HIV, researchers have found.

The study is the first of a gel with an integrase inhibitor, one of the latest additions to the arsenal of drugs for the treatment of HIV but just one of the many compounds or drug combinations that researchers are hoping will be a stronghold for HIV prevention.

The experimental vaginal microbicide gel containing a drug from a class of antiretrovirals (ARVs) not previously examined for use as a topical prevention approach provided significant protection in preventing vaginal transmission of simian/human immunodeficiency virus (SHIV) - a combination of HIV and a related monkey virus - among macaques, reported Dr. Charles Dobard, and Dr. Walid Heneine, of the U.S. Centers for Disease Control and Prevention.

Integrase inhibitors, the latest weapon in the HIV treatment armamentarium, stop HIV from incorporating its genetic information into the DNA of an infected T cell, essentially heading off HIV's master plan to hijack all future generations of cells.

They are intended to be used in combination with other ARVs that target different steps in the HIV life cycle.

Studies have found that integrase inhibitors can suppress virus that is resistant to some of these other ARVs, including those in a class called nucleoside/nucleotide reverse transcriptase inhibitors.

The researchers tested the ability of the compound L-870812 to protect against infection with SHIV.

The gel was applied vaginally to three pigtailed macaques twice a week for seven weeks.

Thirty minutes after each gel application, the animals were exposed to SHIV, for a total of 14 "challenges." A fourth animal received a placebo gel in the same manner.

Two of the three macaques receiving the active gel remained uninfected after seven weeks of being exposed to SHIV.

The third macaque became infected after seven challenges, while the macaque that received a placebo gel became infected after the third exposure.

Importantly, the animal that became infected while using the active gel had no evidence of drug resistant virus even after continuing the gel regimen for an additional 15 weeks.

This is significant because one of the concerns with ARV-containing gels is that the inadvertent use of these gels in someone who is HIV-infected could allow the virus to become resistant and limit treatment options in the future.

While the results are promising, additional studies will be needed before deciding whether to advance this particular vaginal gel to trials in humans.

The study was reported at the International Microbicides Conference in Pittsburgh.

Source: ANI

News A-Z
What's New on Medindia
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
Test Your Knowledge About Chromosomes?
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs Prostitution: Fresh Stakes in the Oldest Trade HIV Symptom 

Most Popular on Medindia

Find a Hospital Post-Nasal Drip Find a Doctor Pregnancy Confirmation Calculator Loram (2 mg) (Lorazepam) Diaphragmatic Hernia Turmeric Powder - Health Benefits, Uses & Side Effects Accident and Trauma Care Drug Interaction Checker Daily Calorie Requirements
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

Sexual Problem

Consult an Expert


Vaginal Gel That Could Protect From HIV Developed Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests