About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Shed Light on How Metabolic System Breaks Down in Obesity

by Kathy Jones on December 20, 2013 at 7:54 PM
Font : A-A+

 Researchers Shed Light on How Metabolic System Breaks Down in Obesity

The process through which the metabolic system breaks down in obesity has been revealed by researchers at University of Michigan. This finding could provide evidence on whether a drug currently being tested at the university can reverse obesity, Type 2 diabetes and fatty liver disease in humans.

In a paper scheduled for online publication in the journal eLife on Dec. 24, Alan Saltiel, the Mary Sue Coleman Director of the Life Sciences Institute, explains how, in obesity, fat cells stop responding to hormones known as catecholamines that trigger them to expend more energy. However, the fat cells of obese mice treated with a drug called amlexanox regained sensitivity to catecholamines, burned the excess energy and returned to normal size.

Advertisement

Next month, scientists at U-M will begin a placebo-controlled clinical trial of amlexanox to test its efficacy as a drug for treating obesity and diabetes in humans. Formulations of amlexanox are prescribed in different international markets to treat asthma and canker sores.

Obesity leads to a state of chronic, low-grade inflammation in liver and fat tissue. Scientists believe that inflammation links obesity and insulin resistance via a pathway called NFkB, which is involved in the regulation of a range of cellular processes and activated in obesity.
Advertisement

Activation of NFkB increases the levels of a pair of genes, IKKε and TBK1, which in turn reduce the ability of certain receptors in the fat cells of obese mice to respond to catecholamines like adrenaline, "fat-burning" hormones generated by the sympathetic nervous system in response to stress.

"We've suspected that in obesity, fat cells become less sensitive to catecholamines such as adrenaline, and that this reduced sensitivity in turn reduces energy expenditure, but the details of this haven't been fully understood," Saltiel said.

High levels of IKKε and TBK1 also resulted in lower levels of a second messenger molecule called cAMP, which increases energy expenditure by elevating fat burning.

Amlexanox interfered with the two enzymes and restored sensitivity to catecholamine, allowing the fat cells to burn energy.

In research published in February 2013, Saltiel found that amlexanox reversed obesity, diabetes and fatty liver in mice. The forthcoming eLife paper explains in part how amlexanox works.

"There is considerable evidence to suggest that in states of obesity, adipose tissue becomes less sensitive to catecholamines because IKKε and TBK1 act as a sort of brake on metabolism, and that this reduced sensitivity in turn reduces energy expenditure," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system of mice to burn more and possibly store less energy in response to catecholamines."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Obesity Bulimia Nervosa Liposuction Battle of the Bulge Diabesity Hunger Fullness and Weight Control Diet and Nutrition for Healthy Weight Loss Diabetes Type 2 and Its Link to Sugar-Sweetened Beverages Carbohydrates and Its Role in Obesity 

Recommended Reading
Metabolic Syndrome
Metabolic Syndrome is associated with sedentary lifestyle .It makes a person more prone to ......
Diabesity
With more than one billion people affected, diabesity is the largest epidemic in the world today. .....
Diabetes Type 2 and Its Link to Sugar-Sweetened Beverages
Sugar-sweetened beverages contribute to metabolic syndrome leading to higher risk for type-2 ......
Battle of the Bulge
The ‘battle of bulge’ is the toughest of all battles. Once you put on weight it is so difficult to g...
Bulimia Nervosa
The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followe...
Carbohydrates and Its Role in Obesity
Obesity is a global epidemic with majority of the world’s population in developed countries being ov...
Diet and Nutrition for Healthy Weight Loss
Correct diet and a planned exercise regime is the mantra of healthy and sustainable weight loss....
Hunger Fullness and Weight Control
An erratic way of eating or any metabolic disturbance in the hunger fullness signals is one of the m...
Liposuction
Liposuction is a cosmetic procedure, which is used to suck out the excess or abnormal fat deposition...
Obesity
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the heal...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use