About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Research Links Obesity and the Body's Production of Fructose

by Thilaka Ravi on September 11, 2013 at 7:00 PM
Font : A-A+

Research Links Obesity and the Body's Production of Fructose

The cause of obesity and insulin resistance may be tied to the fructose your body makes in addition to the fructose you eat, researchers at the University of Colorado School of Medicine observe.

In recent years the role of added sweeteners, such as high fructose corn syrup and table sugar (sucrose), has taken center stage as risk factors for obesity and insulin resistance. Numerous studies suggest that the risk from added sugars may be due to the fructose content.

Advertisement

But in the study published in the Sept. 10 edition of Nature Communications, the team led by researchers at the CU School of Medicine reports that fatty liver and insulin resistance may also result from fructose produced in the liver from non-fructose containing carbohydrates.

The study, whose first authors are Miguel Lanaspa, PhD, and Takuji Ishimoto, MD, reported that mice can convert glucose to fructose in the liver, and that this conversion was critical for driving the development of obesity and insulin resistance in mice fed glucose.
Advertisement

"Our data suggests that it is the fructose generated from glucose that is largely responsible for how carbohydrates cause fatty liver and insulin resistance," said Lanaspa.

Richard Johnson, MD, professor of medicine and chief of the division of renal diseases and hypertension at the School of Medicine and senior author of the paper, said: "Our studies provide an understanding for why high glycemic foods may increase the risk for obesity and insulin resistance. While some of the weight gain is driven by the caloric content and the effects of stimulating insulin, the ability of high glycemic foods to cause insulin resistance and fatty liver is due in part to the conversion of glucose to fructose inside the body.

"Ironically, our study shows that much of the risk from ingesting high glycemic foods is actually due to the generation of fructose, which is a low glycemic sugar. These studies challenge the dogma that fructose is safe and that it is simply the high glycemic carbohydrates that need to be restricted."



Source: Eurekalert
Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Obesity News

 Diabesity: Discovering the Connecting Link Between Obesity and Diabetes
Researchers examine the role of unknown protein NOTCH2-associated receptor2 (MINAR2) in obesity and diabetes using generated Minar2 knockout (KO) mice.
Beyond the Scalpel: Study Debunks Weight Loss Expectations Post Surgery
Study reports that body contouring after bariatric surgery does not contribute to long-term weight loss in patients with massive weight loss.
Revamping Weight Loss Solutions Using Anti-Obesity Medication
Recently FDA-approved drug semaglutide has proven as a highly effective anti-obesity medication showcasing remarkable weight loss benefits.
Exploring Microbiota's Influence on Weight Development
Gut bacteria profile and abundance in toddlers can serve as a predictive factor for their body mass index (BMI) at age 5, irrespective of premature birth status.
What Are the Consequences of Uncontrolled Hunger in Teenagers Living With Obesity?
Obese individuals were found to have weaker appetite regulation, with factors that inhibit eating behavior.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Research Links Obesity and the Body's Production of Fructose Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests