The cause of obesity and insulin resistance may be tied to the fructose your body makes in addition to the fructose you eat, researchers at the University of Colorado School of Medicine observe.
In recent years the role of added sweeteners, such as high fructose corn syrup and table sugar (sucrose), has taken center stage as risk factors for obesity and insulin resistance. Numerous studies suggest that the risk from added sugars may be due to the fructose content.
Fructose - The Toxic Sugar
Sugar in terms of caloric value is similar to starch, but in terms of metabolic effects, it is far different. It comes with a special payload.
Advertisement
But in the study published in the Sept. 10 edition of Nature Communications, the team led by researchers at the CU School of Medicine reports that fatty liver and insulin resistance may also result from fructose produced in the liver from non-fructose containing carbohydrates.
The study, whose first authors are Miguel Lanaspa, PhD, and Takuji Ishimoto, MD, reported that mice can convert glucose to fructose in the liver, and that this conversion was critical for driving the development of obesity and insulin resistance in mice fed glucose.
![Mantra to Prevent Childhood Obesity – Vigorous Physical Activity]( "Mantra to Prevent Childhood Obesity – Vigorous Physical Activity")
Being physically very active is the mantra to prevent pediatric obesity rather than concentrating efforts at restricting energy consumption.
"Our data suggests that it is the fructose generated from glucose that is largely responsible for how carbohydrates cause fatty liver and insulin resistance," said Lanaspa.
Richard Johnson, MD, professor of medicine and chief of the division of renal diseases and hypertension at the School of Medicine and senior author of the paper, said: "Our studies provide an understanding for why high glycemic foods may increase the risk for obesity and insulin resistance. While some of the weight gain is driven by the caloric content and the effects of stimulating insulin, the ability of high glycemic foods to cause insulin resistance and fatty liver is due in part to the conversion of glucose to fructose inside the body.
"Ironically, our study shows that much of the risk from ingesting high glycemic foods is actually due to the generation of fructose, which is a low glycemic sugar. These studies challenge the dogma that fructose is safe and that it is simply the high glycemic carbohydrates that need to be restricted."
Source: Eurekalert
Mantra to Prevent Childhood Obesity – Vigorous Physical Activity
Being physically very active is the mantra to prevent pediatric obesity rather than concentrating efforts at restricting energy consumption.
Advertisement
"Our data suggests that it is the fructose generated from glucose that is largely responsible for how carbohydrates cause fatty liver and insulin resistance," said Lanaspa.
Richard Johnson, MD, professor of medicine and chief of the division of renal diseases and hypertension at the School of Medicine and senior author of the paper, said: "Our studies provide an understanding for why high glycemic foods may increase the risk for obesity and insulin resistance. While some of the weight gain is driven by the caloric content and the effects of stimulating insulin, the ability of high glycemic foods to cause insulin resistance and fatty liver is due in part to the conversion of glucose to fructose inside the body.
"Ironically, our study shows that much of the risk from ingesting high glycemic foods is actually due to the generation of fructose, which is a low glycemic sugar. These studies challenge the dogma that fructose is safe and that it is simply the high glycemic carbohydrates that need to be restricted."
Source: Eurekalert
Obesity
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the health of the individual. It can affect children and adults.
Advertisement
 Body Mass IndexBody mass index (BMI) is a simple tool that is generally used to estimate the total amount of body fat. | Advertisement
|
Advertisement
Recommended Readings
Latest Obesity News
Researchers examine the role of unknown protein NOTCH2-associated receptor2 (MINAR2) in obesity and diabetes using generated Minar2 knockout (KO) mice.
Study reports that body contouring after bariatric surgery does not contribute to long-term weight loss in patients with massive weight loss.
Recently FDA-approved drug semaglutide has proven as a highly effective anti-obesity medication showcasing remarkable weight loss benefits.
Gut bacteria profile and abundance in toddlers can serve as a predictive factor for their body mass index (BMI) at age 5, irrespective of premature birth status.
Obese individuals were found to have weaker appetite regulation, with factors that inhibit eating behavior.