About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Proteins Could Help Advance Drug Delivery in Living Systems

by Bidita Debnath on February 21, 2016 at 1:51 AM
Font : A-A+

 Proteins Could Help Advance Drug Delivery in Living Systems

There are countless ways to survive on Earth. Some bacteria that live inside paramecia, which are tiny aquatic organisms, use a coiled protein ribbon that unfurls like a Chinese paper yo-yo to deliver a toxin to threatening organisms.

The protein packs a punch, bursting through membranes of the paramecia's competitors as it elongates. Now, in the journal ACS Synthetic Biology, scientists report that the protein could someday deliver drugs or become integrated into tiny devices.

Advertisement


In a search for methods to deliver pharmaceuticals or program cells, researchers have figured out how to package drugs, DNA and RNA into little biological pouches called vesicles. Getting them out to do their job in a cell, however, is another challenge. So, scientists have looked to a strain of paramecium that deploys hitchhiking bacteria to fight off other strains.

The bacteria contain coiled protein polymers called R bodies that, once inside a target organism, unroll into tubes that puncture internal membranes to release bacterial toxins. Pamela A. Silver and Jessica K. Polka wanted to see if they could tune R bodies for potential use in cellular engineering.
Advertisement

The researchers found that they could control the sensitivity of R bodies, making them unfurl at higher or lower pH. Lab testing on E. coli showed the proteins could burst open 60 percent of bacterial cells in acidic conditions.

Because they work rapidly and reversibly, the researchers say the R bodies could be used in a variety of biotechnology applications to target the delivery of molecules inside living systems. The proteins could also serve as switches in microelectromechanical systems, or MEMS.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity Magical Millets for Your Health Baby Food - Basics Nutrition IQ Nanotechnology Drug Delivery System 3D Printing in the Pharmaceutical Industry: Technology and Future 

Most Popular on Medindia

Sinopril (2mg) (Lacidipine) The Essence of Yoga Iron Intake Calculator Vent Forte (Theophylline) Pregnancy Confirmation Calculator Drug Interaction Checker Find a Hospital Indian Medical Journals A-Z Drug Brands in India Daily Calorie Requirements
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Proteins Could Help Advance Drug Delivery in Living Systems Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests