Pre-surgical immunotherapy was found to show promise in trial for patients with early stage lung cancer, revealed interim results of a large, multicenter trial to be presented at ASCO Annual Meeting.
Participants in the trial had surgically removable NSCLC ranging from stage IB to IIIB. Patients were treated with two cycles of atezolizumab, which blocks the PD-L1 immune checkpoint protein on some cancer cells, then had surgery to remove the lung cancer tissue.
Lung Cancer
Lung cancer is a malignant tumor in the lung tissues. Smoking is the main cause of lung cancer with symptoms like recurrent respiratory diseases.
Advertisement
‘Immune checkpoint therapy is included as a standard of care for patients with advanced (metastatic) lung cancer, and this study suggests that it may also have benefit in early stage, operable lung cancer.’
Tweet it Now
The results to be reported today involve the first 101 participants in the trial, 90 of whom had surgery following treatment with atezolizumab. Excluding eight patients whose cancers had driver mutations, 15 participants (representing 18% of the total) had a major pathologic response to the treatment, defined as 10% or fewer viable cancer cells detected in the surgically removed tumor tissue. Four patients had a pathological complete response, an absence of residual cancer following the neoadjuvant therapy. Seventy-two of the participants had stable disease, and four had their disease progress.
Treatment related adverse events rated as Grade 3 or 4 - considered severe or urgent - occurred in six of the 90 participants.
Researchers will present Abstract #8503 at the Lung Cancer--Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers session on Saturday, June 1 at 2:15 p.m. CT in Hall D2 of the McCormick Place.
![Quiz on Lung Cancer (Advance)]( "Quiz on Lung Cancer (Advance)")
Lung cancer, like other cancers, is a dreaded condition responsible for a number of deaths in both men and women. Test your knowledge on lung cancer by taking this quiz.
The senior author of the study is David P. Carbone, MD, PhD, of Ohio State University. Co-authors are Valerie Rusch, MD, and Jamie Chaft, MD, of Memorial Sloan Kettering Cancer Center; Bruce Johnson, MD, of Dana-Farber; Alan Nicholas, PhD, See Phan, MD, Katja Schulze, PhD, and Ann Johnson, MBA, of Genentech Inc.; Ignacio Wistuba, MD, of MD Anderson Cancer Center; Robert Merritt, MD, of Ohio State University; Jay M Lee, MD, of UCLA David Geffen School of Medicine; Paul Bunn, MD, of the University of Colorado; Yan Tang, PhD, of Brigham and Women's; Saiama N Waqar, MD, and Alexander Patterson, MD, of Washington University School of Medicine; Eric Haura, MD, and Eric M. Toloza, MD, of H. Lee Moffitt Cancer Center; and Karen L Reckamp, MD, and Dan Raz, MD, of City of Hope Comprehensive Cancer Center. Supported by Genentech, Inc. and the Lung Cancer Research Foundation.
Source: Eurekalert
Researchers will present Abstract #8503 at the Lung Cancer--Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers session on Saturday, June 1 at 2:15 p.m. CT in Hall D2 of the McCormick Place.
Quiz on Lung Cancer (Advance)
Lung cancer, like other cancers, is a dreaded condition responsible for a number of deaths in both men and women. Test your knowledge on lung cancer by taking this quiz.
Advertisement
The senior author of the study is David P. Carbone, MD, PhD, of Ohio State University. Co-authors are Valerie Rusch, MD, and Jamie Chaft, MD, of Memorial Sloan Kettering Cancer Center; Bruce Johnson, MD, of Dana-Farber; Alan Nicholas, PhD, See Phan, MD, Katja Schulze, PhD, and Ann Johnson, MBA, of Genentech Inc.; Ignacio Wistuba, MD, of MD Anderson Cancer Center; Robert Merritt, MD, of Ohio State University; Jay M Lee, MD, of UCLA David Geffen School of Medicine; Paul Bunn, MD, of the University of Colorado; Yan Tang, PhD, of Brigham and Women's; Saiama N Waqar, MD, and Alexander Patterson, MD, of Washington University School of Medicine; Eric Haura, MD, and Eric M. Toloza, MD, of H. Lee Moffitt Cancer Center; and Karen L Reckamp, MD, and Dan Raz, MD, of City of Hope Comprehensive Cancer Center. Supported by Genentech, Inc. and the Lung Cancer Research Foundation.
Source: Eurekalert
Lung Cancer - Top 10 Interesting Facts You Must Know
Lung cancer can be diagnosed only in the advanced stages of the disease. Therefore, early screening is recommended for a better prognosis.
Advertisement
 Steroids to Decrease Lung Cancer Risk in COPD PatientsAnew UBC analysis shows that these medicated devices may also reduce patients' risk of lung cancer by 25 to 30 per cent. | Advertisement
|
Advertisement
Recommended Readings
Latest Cancer News
The combination of the personalized cancer vaccine with ACT led to ovarian cancer control in few patients within a span of three months, stated study results.
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer.
The study findings validate metal-enhanced photo-oxidation for future metal-based anticancer drugs.
Mutations in 11 genes are linked to aggressive forms of prostate cancer, which may present novel therapeutic and therapy options.
Improved oral health, as indicated by the count of natural teeth and dental appointments preceding the diagnosis, correlated with enhanced head and neck cancer survival rates.
