The Ebola epidemic has ravaged West Africa for more than a year now. Researchers are working on finding an effective vaccine against the deadly Ebola virus. A new study claimed that an experimental Ebola vaccine called VSV-EBOV appears safe and generates immune response in a small phase 1 clinical trial.
Scientists at the Public Health Agency of Canada's National Microbiology Laboratory originally developed the VSV-EBOV vaccine. The vaccine does not contain Ebola virus and cannot cause Ebola virus disease.
Ebola Virus Disease
Ebola is caused by a virus via direct contact with body fluids or infected blood. Scientists have identified five types of Ebola or Ebola hemorrhagic fever virus.
Advertisement
Two independent but coordinated studies, performed at the Walter Reed Army Institute of Research (WRAIR) and the National Institute of Allergy and Infectious Diseases (NIAID), explored the safety and immunogenicity of the Ebola vaccine when administered at different dosages. Lt. Col. Jason Regules, co-lead author of the study said, "These pivotal early studies helped inform dose selection for testing of VSV-EBOV vaccine in a large-scale clinical trial in West Africa. We were gratified to see that the vaccine was not associated with significant adverse effects in this very carefully monitored study."
During the trials, researchers collectively enrolled 52 volunteers who received either the vaccine candidate or a placebo. Volunteers who were given the vaccine received one of two different doses and volunteers were assessed on days 1, 3, 7, 14, and 28 to see if they developed anti-Ebola antibodies. The researchers found that 26 of 28 volunteers in the vaccine group showed the intended Ebola glycoprotein antibody response within two weeks of vaccination, and all of the volunteers had antibodies within 28 days of receiving the vaccine. Researchers saw a higher antibody response in the vaccine recipients who received the higher vaccine dose.
![World Support for Ebola: US$35 Million Funding from King Abdallah of Saudi Arabia]( "World Support for Ebola: US$35 Million Funding from King Abdallah of Saudi Arabia")
Zaire ebolavirus is commonly known as Ebola. It was previously known as ebola haemorrhagic fever and is a deadly human illness.
Col. Stephen Thomas, senior author of the study, said, "Researchers saw a robust immune response following a single dose of the vaccine, which could be particularly useful in outbreak interventions. We were able to leverage the WRAIR's experience in conducting ethical and safe clinical research experiments to meet a global need."
The study has been published in the New England Journal of Medicine.
Source: Medindia
World Support for Ebola: US$35 Million Funding from King Abdallah of Saudi Arabia
Zaire ebolavirus is commonly known as Ebola. It was previously known as ebola haemorrhagic fever and is a deadly human illness.
Advertisement
Col. Stephen Thomas, senior author of the study, said, "Researchers saw a robust immune response following a single dose of the vaccine, which could be particularly useful in outbreak interventions. We were able to leverage the WRAIR's experience in conducting ethical and safe clinical research experiments to meet a global need."
The study has been published in the New England Journal of Medicine.
Source: Medindia
Ontario Patient With Symptoms of Ebola Tests Negative at Sunnybrook
The patient had returned to Canada from West Africa 10 days earlier and was put into isolation as a precaution when Ebola-like symptoms began to appear.
Advertisement
Liberia Reports First Ebola Infection After a MonthAfter suffering over 4,000 deaths due to the deadly virus, Liberia was supposed to be declared Ebola-free by mid-April. A new case is a major setback. | Advertisement
|
Advertisement
Recommended Reading
Latest Tropical Disease News
Mumbai's TechInvention Lifecare and South Korean Eubiologics team up to introduce oral cholera vaccine in India after successful phase III clinical trial.
Scientists have found that the dengue virus has become more severe in India, highlighting the urgent need for vaccines that target the strains found in the country.
It is important to consider malarial infection in cases of acute kidney injury in someone with a travel history from endemic areas to improve treatment outcomes.
Ghana approves the use of the University of Oxford's malaria vaccine, produced by the Serum Institute of India (SII), becoming the first country to adopt the new vaccine.
The dengue virus combines molecules from its RNA with mosquito saliva to foil the human immune system and spread dengue fever and related diseases.