The likeliness of the protein being significant for other inflammatory diseases is quite high.
The research results have been published in the American journal Gastroenterology.Excessive alcohol intake and gall stones are known risk factors for acute pancreatitis. However, as yet no explanation has been found for what actually happens in the body in cases of acute pancreatitis. Current research shows that calcium-sensitive proteins found in the body, for example calcineurin, promote inflammation, but it is not known exactly how.Henrik Thorlacius and Maria Gomez at the University's Department of Clinical Sciences in Malmö have investigated this in more detail.
The focus is on a family of proteins linked to calcineurin, called NFAT, the role of which in acute pancreatitis has not previously been studied. "The protein has an unexpectedly major role in the development of inflammation in the pancreas. Now there is a clear target for the development of drugs and treatments", says Henrik Thorlacius, Professor of Surgery at Lund University and a doctor at Skåne University Hospital.In experiments on mice, the researchers found a number of links between NFAT and acute pancreatitis.
The findings open up new opportunities for research on treatment and drugs, both for acute pancreatitis and for other acute inflammatory diseases, such as blood poisoning and inflammatory bowel disease."An effective drug needs to contain a substance that stops the activation of NFATc3 without producing serious side-effects", says Professor Thorlacius.The NFAT proteins function as transcription factors, which means that they can be bound to the body's DNA and regulate the expression of specific genes in different cells. They have so far primarily been associated with immune cells.