About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Pancreatitis Treatments may be Spawned by Study

by Rajashri on June 30, 2009 at 8:59 PM
Font : A-A+

 New Pancreatitis Treatments may be Spawned by Study

The condition in which the pancreas digests itself and surrounding tissue is often fatal and is called pancreatitis. Alcohol can trigger the condition by combining with fatty acids in the pancreas, scientists have previously revealed. Once calcium ions enter cell fluid in the pancreas it activates digestive enzymes and damages the cells.

The team, in collaboration with the RIKEN Brain Science Institute in Japan, have now identified channels within special stores that allow calcium to enter the fluid inside pancreatic cells. They have also found that toxic calcium release can be significantly reduced if the gene responsible for the production of these channels is 'deleted' (or knocked-out).

Advertisement

Professor Ole Petersen, from the University's School of Biomedical Sciences, explains: "The pancreas releases enzymes into the gut, where they become activated and digest our food. When these digestive enzymes are activated inside the cells, however, they start to digest the pancreas itself, causing serious damage and often death. Alcohol is widely recognised as one of the triggers for this process, but the reasons behind it have been unclear.

"We now know that alcohol, in combination with fatty acids, can produce substances that cause an excessive increase in calcium ions in the pancreatic cell water. We have found that this excessive build-up is caused by the movement of calcium ions from special calcium stores into the cell water, which activate digestive enzymes from within the cell. Our new research identifies the channels through which calcium movement occurs and importantly the genes which are responsible for the production of these channels.
Advertisement

"This work highlights the dangers of excessive drinking; the higher the levels of alcohol in the blood, the higher the risk of pancreatitis. Now that we have identified the genes that can control the condition, we should be able to develop more successful treatments for the disease."



Source: Eurekalert
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Pancreatic Cancer Pancreatitis Reye’s Syndrome Hypertriglyceridemia Whipple´s Surgical Procedure Pancreas Transplantation Pancreatectomy Peritonitis Annular Pancreas / Duodenal Birth Defect 

Recommended Reading
Pancreatitis
Pancreatitis or inflammation of the pancreas may show up as acute pancreatitis or chronic pain. ......
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, .....
'Artificial Pancreas' May Be Of Help To Diabetics
British scientists have developed what they call 'artificial pancreas' - a revolutionary insulin ......
Annular Pancreas / Duodenal Birth Defect
Gastrointestinal surgery, Gastroenterology, Medical Genetics...
Hypertriglyceridemia
Triglycerides are a form of the fat, the major energy source found in our blood. High triglyceride l...
Pancreas Transplantation
Pancreas transplant is a surgical procedure involving the replacement of a dysfunctional pancreas in...
Pancreatic Cancer
Pancreatic cancer often involves its exocrine part. It grows aggressively, and often detected late. ...
Peritonitis
Peritonitis, an inflammation of the peritoneum, is caused due to a bacterial or fungal infection tha...
Reye’s Syndrome
Reye's syndrome is a medical emergency chiefly affecting children and teenagers and is marked by the...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use