The condition in which the pancreas digests itself and surrounding tissue is often fatal and is called pancreatitis. Alcohol can trigger the condition by combining with fatty acids in the pancreas, scientists have previously revealed. Once calcium ions enter cell fluid in the pancreas it activates digestive enzymes and damages the cells.
The team, in collaboration with the RIKEN Brain Science Institute in Japan, have now identified channels within special stores that allow calcium to enter the fluid inside pancreatic cells. They have also found that toxic calcium release can be significantly reduced if the gene responsible for the production of these channels is 'deleted' (or knocked-out).
Professor Ole Petersen, from the University's School of Biomedical Sciences, explains: "The pancreas releases enzymes into the gut, where they become activated and digest our food. When these digestive enzymes are activated inside the cells, however, they start to digest the pancreas itself, causing serious damage and often death. Alcohol is widely recognised as one of the triggers for this process, but the reasons behind it have been unclear.
"This work highlights the dangers of excessive drinking; the higher the levels of alcohol in the blood, the higher the risk of pancreatitis. Now that we have identified the genes that can control the condition, we should be able to develop more successful treatments for the disease."