About Careers MedBlog Contact us

Novel Breast Cancer Test

by Sheela Philomena on December 7, 2011 at 12:34 PM
Font : A-A+

 Novel Breast Cancer Test

A new multigene test has been developed by scientists to identify the risk of recurrence of breast cancer.

The method combines measuring tumor gene expression with a gene expression algorithm to decipher the genetic underpinnings of a patient's cancer and determine whether the individual patient should be treated with surgery (usually lumpectomy) or a combination of surgery and radiation.


This is the first time a multigene test has been used to differentiate lower-risk and more aggressive forms of ductal carcinoma in situ (DCIS) and will allow physicians to spare many patients the need to undergo radiation, according to researchers.

Lawrence J. Solin, M.D., FACR, FASTRO, chair of the department of radiation oncology at Einstein Medical Center in Philadelphia, presented the results at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium (SABCS), held Dec. 6-10, 2011.

"Using a molecular-based assay, we have successfully identified patients at higher risk for recurrence and patients at lower risk," said Solin. "This is an important advance for women with newly diagnosed DCIS. By predicting individual risk, physicians can provide a more tailored treatment program for each patient."

The validation study of the DCIS Score was a collaboration among the Eastern Cooperative Oncology Group (ECOG), North Central Cancer Treatment Group and Genomic Health. The validation utilized patient tumor samples from E5194, an ECOG-led, multi-institutional study of patients with low-, intermediate- or high-grade DCIS who had been treated surgically but had not received radiation. E5194 was the first prospective study of local excision alone for DCIS, and its five-year results were reported at SABCS in 2006 (L. Hughes).

Researchers tested and scored tumors from 327 patients to determine their risk for recurrence. The DCIS validation study team used the Oncotype DX breast cancer assay, which has been available for invasive breast cancer since 2004, and a DCIS Score algorithm to study these tumor samples.

The test uses reverse transcriptase-polymerase chain reaction technology, which quantitates the level of RNA in the individual tumor sample to reveal its underlying biology. The level of RNA is then used by a prespecified algorithm to calculate a DCIS Score, which predicts the likelihood of local recurrence, defined as either the development of a new invasive breast cancer or the recurrence of DCIS.

Solin also reported 10-year results of E5194, in which 46 patients had an ipsilateral breast event (IBE; defined as ipsilateral local recurrence of DCIS or invasive cancer) at a median follow-up of 8.8 years. Continuous DCIS Score was significantly associated with IBE when adjusted for tamoxifen use and provided value beyond the traditional measures of tumor size, tumor grade and margin status.

Numerous studies, including the current study, have shown that routine, microscopic pathology grading is not a reliable indicator of the risk for recurrence.

"The DCIS Score will help physicians understand the underlying biology of DCIS for an individual patient and accurately gauge the risk for that person," said Solin. "As a result, the patient and physician can decide on the appropriate course of treatment based on a more complete understanding of the risk involved."

Source: Eurekalert

News A-Z
What's New on Medindia
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Tattoos A Body Art Breasts - Structures and Types 

Most Popular on Medindia

Blood Pressure Calculator Sinopril (2mg) (Lacidipine) The Essence of Yoga Nutam (400mg) (Piracetam) Noscaphene (Noscapine) How to Reduce School Bag Weight - Simple Tips Hearing Loss Calculator Drug Side Effects Calculator Daily Calorie Requirements Selfie Addiction Calculator
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Novel Breast Cancer Test Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests