by Colleen Fleiss on  December 24, 2019 at 3:09 PM Research News
New, Potential Target for Restoring Movement After Spinal Cord Injury Discovered
After a spinal cord injury the neuromodulation of interrupted lumbar motor circuits by neurotrophic therapy improved locomotor performance, stated the team led by Xiao-Ming Xu, PhD. These findings are being published in the December issue of Nature Communications.

"There are no definitive treatments yet for SCI patients," said Han. "However, hope for restoring motor function continues to rise, for good reason. We find that, despite no direct damage from thoracic SCI, the lumbar circuit undergoes a profound neurodegeneration, which we have highlighted as a promising new therapeutic target for promoting neuroprotection."

SCI disrupts pathways at the injury site and affects MNs by causing their dendrites to withdraw or atrophy below the injury, which can lead to diminished movement or locomotor function.


Previously, the research team was able to improve locomotor recovery and reduce MN dendritic atrophy after a moderate, contusive SCI at the ninth thoracic level, by transporting Neurotrophin-3 (NT-3) to lumbar MNs. NT-3 is known as a trophic factor that contributes neuronal survival and growth. These latest research findings extend the role of NT-3 to modulating propriospinal-MN circuit reorganization, which accounts for improvement of locomotor function after SCI.

Researchers were also able to determine that a moderate injury at the ninth thoracic level stops the corticospinal tract and rubrospinal tract projections down to the spinal cord, but maintains some neural transmissions which can be reinforced by the NT-3 therapy. Additionally, they discovered the spared pathway, made up of a collection of nerve fibers, namely, the descending propriospinal pathway, connecting to the lumbar spinal cord, is functionally associated with NT-3-mediated locomotor recovery after SCI. Their research also suggests that NT-3 supports MN recovery by promoting dendritic regrowth.

"Modulating propriospinal-MN circuitry with NT-3 gene therapy could be an attractive strategy to enable functional recovery after SCI." said Xu.

Source: Eurekalert

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