A new mouse model of Fukuyama's muscular dystrophy developed by researchers copies the pathology seen in the human form of the disease. By removing the gene fukutin from mouse embryos at various points during development, researchers led by Kevin Campbell were able to determine that fukutin disrupts important modifications of dystrophin that prevent the muscle cells from attaching to the ECM. Disruption of the gene earlier in development led to a more severe form of the disease, suggesting that fukutin is important for muscle maturation. Disruptions in later stages of development caused a less severe form of the disease. In a companion piece, Elizabeth McNally of the University of Chicago discusses the implications of this disease model for the development of new therapies to treat muscular dystrophy. Source: Eurekalert << Child Mortality Estimation Methods Elaborated in New PLOS C... New 'Traffic Light' Test Could Benefit Patients With Liver ... >> Recommended Reading Muscular Dystrophy Overview about muscular dystrophy, a muscle disease characterized by muscle weakness and muscle wasting. READ MORE Underlying Causes of Impaired Brain Function in Muscular Dystrophy Explored A new study published by Cell Press has shed light on the molecular missteps that disrupt brain function. READ MORE Researchers Able to Reverse Muscular Dystrophy in Mice Researchers have revealed that by eliminating the buildup of toxic RNA in muscle cells, they were able to reverse the symptoms of myotonic muscular dystrophy in mice. READ MORE Concerns Differ Between Patients And Doctors In Case of Muscular Dystrophy Multi-system diseases like myotonic dystrophy that are complex,entails physicians and patients to identify which symptom impacts quality of life and, accordingly, what treatments should take priority. READ MORE Dysarthria Dysarthria is a condition characterized by speech difficulty due to poor or weak speech muscle control. READ MORE Genetic Testing of Diseases Genetic testing helps to confirm a genetic condition in an individual and involves q complex laboratory techniques READ MORE Most Popular on Medindia Post-Nasal Drip Blood Donation - Recipients Sanatogen More News on: Muscular DystrophyGenetic Testing of DiseasesDysarthria
A new mouse model of Fukuyama's muscular dystrophy developed by researchers copies the pathology seen in the human form of the disease. By removing the gene fukutin from mouse embryos at various points during development, researchers led by Kevin Campbell were able to determine that fukutin disrupts important modifications of dystrophin that prevent the muscle cells from attaching to the ECM. Disruption of the gene earlier in development led to a more severe form of the disease, suggesting that fukutin is important for muscle maturation. Disruptions in later stages of development caused a less severe form of the disease. In a companion piece, Elizabeth McNally of the University of Chicago discusses the implications of this disease model for the development of new therapies to treat muscular dystrophy. Source: Eurekalert << Child Mortality Estimation Methods Elaborated in New PLOS C... New 'Traffic Light' Test Could Benefit Patients With Liver ... >> Recommended Reading Muscular Dystrophy Overview about muscular dystrophy, a muscle disease characterized by muscle weakness and muscle wasting. READ MORE Underlying Causes of Impaired Brain Function in Muscular Dystrophy Explored A new study published by Cell Press has shed light on the molecular missteps that disrupt brain function. READ MORE Researchers Able to Reverse Muscular Dystrophy in Mice Researchers have revealed that by eliminating the buildup of toxic RNA in muscle cells, they were able to reverse the symptoms of myotonic muscular dystrophy in mice. READ MORE Concerns Differ Between Patients And Doctors In Case of Muscular Dystrophy Multi-system diseases like myotonic dystrophy that are complex,entails physicians and patients to identify which symptom impacts quality of life and, accordingly, what treatments should take priority. READ MORE Dysarthria Dysarthria is a condition characterized by speech difficulty due to poor or weak speech muscle control. READ MORE Genetic Testing of Diseases Genetic testing helps to confirm a genetic condition in an individual and involves q complex laboratory techniques READ MORE Most Popular on Medindia Post-Nasal Drip Blood Donation - Recipients Sanatogen More News on: Muscular DystrophyGenetic Testing of DiseasesDysarthria
