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Negative Memory Storage Affects Depression Symptoms: Study

by Colleen Fleiss on August 17, 2019 at 9:03 PM
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Negative Memory Storage Affects Depression Symptoms: Study

Inhibiting negative emotions could be future depression treatment, according to research in mice published in JNeurosci.

Groups of neurons that are activated after an experience are thought to be the physical representation of memory. These so-called engrams in the hippocampus could be involved in depression, which is characterized by impaired recall of positive memories and increased recall of negative memories.

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In a mouse model of depression, Tak Pan Wong and colleagues at Douglas Hospital Research Centre tagged the engrams that formed after mice experienced social stress and examined their social avoidance behavior. Even though all mice experienced the same stressor, only some displayed depression behaviors, indicating a predisposition to developing depression.

Activating the engram cells increased social avoidance behavior while suppressing the cells decreased it, suggesting a role in the cognitive symptoms of depression.

Source: Eurekalert
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