About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER

New Way to Choose the Sex of Offspring Discovered

by Colleen Fleiss on August 17, 2019 at 8:59 PM
Font : A-A+

New Way to Choose the Sex of Offspring Discovered

A new and reversible chemical treatment was found to segregate X-bearing sperm from Y-bearing sperm, stated new study by Masayuki Shimada and colleagues at Hiroshima University, published in the open-access journal PLOS Biology. The study was performed in mice, but the technique is likely to be widely applicable to other mammals as well.

Most cells from male mammals contain both an X and a Y chromosome, but during sperm development (spermatogenesis), the X and Y chromosomes are segregated into different cells so that an individual sperm will carry either one or the other, with an X chromosome giving rise to daughters and a Y chromosome to sons.



Unlike the Y chromosome, which carries very few genes, the X chromosome carries many, some of which remain active in the maturing sperm. This difference in gene expression between X- and Y-bearing sperm provides a theoretical basis for distinguishing the two.

They focused on a pair of receptors called Toll-like receptor 7 and 8 (TLR7/8) and found that a chemical that bound to the receptors slowed sperm motility without impairing either sperm fertilization ability or viability. They showed the effect was due to impaired energy production within the sperm and could be reversed by removal of the chemical from the medium. Treatment of mouse sperm with this X-retarding chemical, followed by in vitro fertilization with the fastest swimmers, led to litters that were 90% male. When the slower swimmers were used instead, the litters were 81% female.

There are other procedures that can be used to separate X and Y sperm, but they are cumbersome, expensive, and risk damaging the DNA of the sperm. The procedure developed by these authors has the potential to greatly simplify sex selection for either in vitro fertilization (in which sperm and egg join in a lab dish) or artificial insemination (in which sperm are implanted into the female reproductive tract). Such techniques are widely used in the agricultural animal breeding field, as well as in human assisted reproduction.

"The differential expression of receptor genes by the two sex chromosomes provides the basis for a novel and potentially highly useful method for separating X and Y sperm and we have already succeeded the selectively production of male or female in cattle and pig by this method," Shimada said. "Nonetheless, use of this method in human reproductive technology is speculative at the moment, and involves significant ethical issues unaffected by the utility of this new technique."

Source: Eurekalert

News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Link between Dietary Intake of Plant-based Essential Fatty Acids and Death Risk
Aspirin may be Harmful When Used for Preventing 1st Heart Attack, Stroke
Pregnancy Complications Elevated Among Symptomatic COVID-19 Women
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Sex Facts Prostitution: Fresh Stakes in the Oldest Trade Sexual Intercourse Facts Safe Sex Top Ten Trivial Sex Facts Top Ten Sex Tips for Men Sex Numbers Neck Cracking 

Recommended Reading
Spermatocele
Spermatocele is a condition in which there is a blockage in the epididymal duct, resulting in semen ...
Sperm Production in Transgender Patients is Possible but Not Certain
Young transgender women can recover their fertility to some extent after starting and stopping ......
Secret Handshake Between Sperm and Uterus Detected
Uterine cells express a receptor that recognizes a glycan molecule on the surface of sperm cells, .....
Frozen Sperm found Viable in Space like on Earth
Human sperm samples exposed to microgravity are just as active and concentrated as on Earth, ......
Neck Cracking
Neck cracking or neck popping is caused by quick movements to loosen the ligaments and joints of the...
Prostitution: Fresh Stakes in the Oldest Trade
Prostitution has broadened its base to include street prostitution, massage brothels, gigolo outcall...
Safe Sex
Sex is fun but involves health risks such as sexually transmitted diseases (STDs or unplanned pregna...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use