Jakub Halik, a 38-year-old fireman who became the first human ever to have survived six months without a heart passes away.
Physicians treating an aggressive cancerous tumour in his heart removed it in April but were never able to find another compatible donor for a successful transplant.
"Up to now, no one the world over has ever survived such a long time in this kind of condition," the Dnes Czech daily said Thursday.
Meanwhile, the Blesk daily paid homage to "the man without a heart who was a man of great heart."
Black flags of mourning flew over fire stations across the Czech Republic Thursday as colleagues honoured Halik.
In August, eminent cardiologist Jan Pirk from Prague's IKEM experimental medicine institute had warned that finding a heart compatible for a "big lad" like Halek would be no easy task.
His condition deteriorated over the past few weeks with tests showing he was suffering from both liver and kidney failure.
"We did everything possible to save him," Pirk said. Jakub Halik died Saturday morning, but the news was only made public later in the week.
"This feisty fighter loved his family very much. His life's mission was to save the lives of others. Unfortunately, our ability to save his life were very limited," Eliska Breckova, his nurse at IKEM told Blesk.
Halik is survived by his wife and 12-year-old son.