Estrogen receptors in the liver are important in maintaining fertility, according to a recent study. Moreover, the expression of those receptors is under the control of dietary amino acids, the building blocks of proteins. The findings in mice may have important implications for some forms of infertility and for metabolic changes that come with menopause, said the researchers. "This is the first time it has been demonstrated how important the liver is in fertility. The idea that diet may have an impact on fertility isn't totally new of course, but this explains how diet, and especially a diet poor in protein, can have a direct influence," said Adriana Maggi of the University of Milan in Italy. Maggi's team got interested in the liver receptors quite by accident. In studies of mice, "we saw that the organ that always had the highest activation of estrogen receptor was the liver," she said. Initially they thought it must be a mistake and disregarded it, but over time they began to think maybe the mice were telling them something. The researchers have now reported that the expression of those estrogen receptors depends on dietary amino acids. Mice on a calorie-restricted diet and those lacking estrogen receptors in their livers showed a decline in an important hormone known as IGF-1. Blood levels of the hormone dropped to levels inadequate for the correct growth of the lining of their uteruses and normal progression of the estrous cycle, they show. When the calorie-restricted mice were given more protein, their reproductive cycles got back on track. Dietary fats and carbohydrates, on the other hand, had no effect on the estrogen receptors or fertility. The researchers have suggested that this connection between amino acids, estrogen receptor signaling in liver, and reproductive functions may have clinical implications. The results also provide new clues for understanding the increased risk of metabolic and inflammatory disease in menopausal women. The findings have been published in the journal Cell Metabolism, a Cell Press publication.Source: ANI << Children of Divorced Parents Most Often Stay With Mothers, ... Ambulances Upgraded for Overweight Patients >> Recommended Reading Women Aged 35 'are Six Times More Likely to Suffer Fertility Problems' Couples must not to leave it too late to try for a baby as it can lead to fertility problems in women, doctors have warned. READ MORE Warning! Antioxidants May Cause Fertility Problems in Females New research has revealed a possible unexpected side effect of antioxidants: They might cause fertility problems in females. READ MORE Vitamin Supplements may Boost Male Fertility A new research revealed that men with low fertility could be able to father a child if they include certain vitamins and minerals in their diet. READ MORE Fertility Screening Prevents Births With Gene Disorders A couple in East Lothian have become the first in Scotland to go through fertility screening to prevent their second child from being born with cystic fibrosis. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Sanatogen Fongitar (Zinc Pyrithionone) Hearing Loss Calculator More News on: Hepatitis ALiverWilson's DiseaseMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?