Liver Disease in Children: A Hidden Diabetes Risk Factor

Non-alcoholic fatty liver disease (NAFLD) is the most common pediatric liver disease, affecting 5 to 8 million children in the United States. In NAFLD, the cells of the liver store large fat droplets, which can affect the function of the liver. Physicians have long observed a relationship between NAFLD and type 2 diabetes in adults, but much less is known about a similar connection in children.

Fatty Liver in Children Makes Cells Unresponsive to Insulin

The rates of type 2 diabetes have doubled in children over the past 20 years. Children with NAFLD have features of insulin resistance, a key characteristic of type 2 diabetes and so may be at risk for developing the disease.

“There is a growing public health crisis as children with diabetes mature into adults with diabetes. We need to better understand how NAFLD contributes to type 2 diabetes risk in children so that we can actively work to prevent it,” said Jeffrey Schwimmer, MD, professor of pediatrics at the University of California San Diego School of Medicine.

In a new study, published in Clinical Gastroenterology and Hepatology, a team of researchers provide hard numbers describing the connection between NAFLD and diabetes risk.

They found that among 892 children with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network, type 2 diabetes was present in 6.6 percent of the children at initial assessment with the incidence rate increasing 3 percent annually over the next four years.

This is alarming because type 2 diabetes in youth is a much more aggressive disease than in adults, with more immediate and serious complications and outcomes.

They also identified specific factors that increase the risk of type 2 diabetes in children with NAFLD: sex (females were more likely to develop type 2 diabetes), the severity of obesity and the amount of fat and scar tissue in the liver. These findings have clinical implications for gastroenterologists caring for children with NAFLD.



Source-Medindia