Highlights Women with Polycystic ovary syndrome (PCOS) may have an increased risk of non-alcoholic fatty liver disease development. Women who have PCOS have higher levels of male hormones, and so they are less sensitive to insulin and are overweight or obese. These women are two to three times more likely to develop the non-alcoholic fatty liver disease than women without PCOS. Increasing level of male hormone which is responsible for polycystic ovary syndrome (PCOS) in women may also lead to non-alcoholic fatty liver disease, finds a new study. The findings of this study are published in the PLOS Medicine. These women with polycystic ovaries may have a two-fold increased risk of developing non-alcoholic fatty liver disease. Liver Disease- Major Risk for Women With Polycystic Ovary Syndrome This syndrome affects 10 percent of women all over the world and is known to cause irregular periods, impaired fertility, male-pattern body hair growth and acne in them. Increased level of male hormone is found in most women who have PCOS. These women are known to be less sensitive to insulin and are sometimes overweight or obese. Non-alcoholic fatty liver diseases are a range of liver conditions affecting people who drink little or no alcohol and is a major cause of liver disease worldwide; it poses a major risk to everyone because it has been linked to obesity. ‘Women who have PCOS are two to three times more likely to develop the non-alcoholic fatty liver disease than women without PCOS.’ The findings of this study indicate that women who have PCOS are two to three times more likely to develop non-alcoholic fatty liver disease when compared to women without PCOS. And most importantly, they also found that women with both PCOS and increased testosterone level had an increased risk of non-alcoholic fatty liver disease regardless of their weight. In this study, the scientists compared the health records of 63,000 women with PCOS with 120,000 women who were of similar age, body weight and background. They also looked at two cohort studies of women with PCOS and women with high levels of testosterone. Dr. Krish Nirantharakumar from the University of Birmingham's Institute of Applied Health, said: "We observed a two-fold increased risk of fatty liver disease in women with PCOS and male hormone excess". He also added, "Looking at the levels of the major male hormone testosterone, we found that having a high testosterone level increased the risk of fatty liver disease significantly, even in women who were of a normal healthy weight". Professor Wiebke Arlt also said: "Our research has highlighted significant and previously unknown health risks in women with PCOS and increased male hormone levels. "Our findings suggest that regular screening for the fatty liver disease should be considered in these women, to make sure the disease is caught early." "Our research shows that PCOS does not only affect fertility but also comes with significantly increased rates of metabolic complications." "This means that women with PCOS need integrated health care throughout their life and not only when planning a pregnancy," said Professor Wiebke Arlt Reference Balachandran Kumarendran , Michael W. O'Reilly , Konstantinos N. Manolopoulos , Konstantinos A. Toulis, Krishna M. Gokhale, Alice J. Sitch, Chandrika N. Wijeyaratne, Arri Coomarasamy, Wiebke Arlt , Krishnarajah Nirantharakumar. Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United Kingdom primary care database, PLOS Medicinel (2018).https://doi.org/10.1371/journal.pmed.1002542 Source: Medindia << Depression a Risk of Dementia and Mild Cognitive Impairment Discovery of How Cells Grow in Ovarian Cancer may Lead to Ne... >> Recommended Reading PCOS Linked to Anxiety Daughters of women with polycystic ovary syndrome (PCOS) are at a higher risk of developing anxiety, whereas sons often develop obesity and insulin resistance. READ MORE Women Suffering from PCOS Highly Prone to Diabetes Women suffering from Poly Cystic Ovary Syndrome (PCOS), a problem in which a woman's hormones are imbalanced, are highly prone to diabetes. READ MORE PCOS In The Mother Increases Risk Of Autism In The Offspring Women with polycystic ovarian syndrome (PCOS) have increased levels of androgens even during pregnancy, which increases the risk of autism in children. READ MORE Polycystic Ovary Syndrome Among Women Is Overdiagnosed Due to Its Definition Polycystic ovary syndrome (PCOS) definition is unclear whether the impacts are due to the condition or its symptoms or from the psychological effect of being labelled as having PCOS. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Ovarian Cancer Ovarian cancer affects both the ovaries and is referred to as the 'silent killer' as the symptoms go unnoticed until the disease advances. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Blood - Sugar Chart Hearing Loss Calculator Drug - Food Interactions More News on: Hepatitis AOvarian CancerLiverWilson's DiseaseMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?