About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

IRX4204 Alleviates Cognitive Decline In Animal Models Of Alzheimer's Disease

by Bidita Debnath on October 30, 2012 at 11:16 PM
Font : A-A+

 IRX4204 Alleviates Cognitive Decline In Animal Models Of Alzheimer's Disease

New research demonstrates the role of the investigational compound IRX4204 in alleviating cognitive decline in animal models of Alzheimer's disease (AD).

The research was presented in October at the 6th Neurodegenerative Conditions Research and Development Conference in San Francisco.

Advertisement

The presentation entitled "Investigation of the RXR-specific agonist IRX4204 as a Disease Modifying Agent of Alzheimer's Disease Neuropathology and Cognitive Impairment" was made by lead researcher Giulio Maria Pasinetti, MD, PhD, of the Mount Sinai School of Medicine in New York City.

IRX4204 is a retinoid X receptor (RXR) agonist, meaning it stimulates the retinoid receptor in the brain.The data demonstrates attenuation of AD including prevention of plaque deposits associated with cognitive deterioration in an IRX4204-treated mouse model genetically determined to develop AD. IRX4204 also prevents neuropathological features associated with abnormal tau processing, another form of abnormal protein also found in a form of Parkinson's disease associated with dementia.
Advertisement

"The treatment of AD remains a serious unmet medical need which IRX4204 may be able to address," Dr. Pasinetti said "Our research show that IRX4204 and other RXR agonists have potential for slowing, and possibly reversing pathology and cognitive deficits in Alzheimer's disease patients."

Ongoing translational studies in subjects with Alzheimer's disease and Parkinson's disease with dementia are currently being developed.

Alzheimer's disease currently afflicts more than 5 million Americans and may triple in prevalence to more than 16 million Americans by 2050, according to data from The Alzheimer's Association.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Organ Donation Week 2022 - 'Take the Pledge to Save Lives'
Test your Knowledge on Heart Transplantation
Test Your Knowledge on Lung Transplantation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alzheimers Disease Creutzfeldt-Jakob Disease Diet and Alzheimer´s Disease Genetics of Alzheimer´s disease Top 15 Toxic Chemicals Affecting Brain Development In Children Mini-Mental Scale (Cognitive Function Test) 

Most Popular on Medindia

Find a Hospital How to Reduce School Bag Weight - Simple Tips Accident and Trauma Care Color Blindness Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Pregnancy Confirmation Calculator Vent Forte (Theophylline) Sanatogen Loram (2 mg) (Lorazepam) Diaphragmatic Hernia
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use