About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Inflammatory Bowel Disease may be Treated by Intestinal Bacteria

by Rajashri on October 17, 2008 at 2:17 PM
Font : A-A+

 Inflammatory Bowel Disease may be Treated by Intestinal Bacteria

Specific types of bacteria in the intestine trigger the production of pro-inflammatory immune cells, according to researchers from NYU Langone Medical Centre. This finding can lead to new therapies for inflammatory bowel disease.

In the study conducted using mouse model, the researchers found that ytophaga-flavobacter-bacteroidetes (CFB) bacteria were associated with the creation of Th17 cells.

Advertisement

The bacteria play a crucial role in digestion and protect against pathogens by outcompeting harmful bacteria.

"It's not the amount of microbial flora but the kind of microbial flora that seems to count," said Dr. Dan Littman, NYU School of Medicine.

He said that identifying the specific species of bacteria that influence the balance of inflammatory cells, could lead to more sophisticated treatments that fine-tune bacteria in the intestine and, in turn, dampen the production of inflammatory cells.
Advertisement

During the study, Littman's team observed that newborn mice that remain isolated from bacteria never generate any of these cells. They begin to generate the cells only after they begin to eat food and ingest bacteria.

These observations suggested that the introduction of bacteria in the gut is associated with the creation of Th17 cells.

For the study, the team gave normal, bacteria-filled mice antibiotics that selectively killed some of the bacteria in their small intestine. Some of these antibiotics also depleted their Th17 cells, indicating for the first time a causal link between specific bacteria and the generation of inflammatory cells.

They found a colony of mice that have intestinal bacteria but do not have Th17 cells. It had different bacteria in their guts than other colonies.

By comparing the intestinal bacteria in mice, the team discovered that cytophaga-flavobacter-bacteroidetes (CFB) bacteria were associated with the creation of Th17 cells.

"There is more and more evidence that gut flora have a tremendously important influence on human health," said Yasmine Belkaid, Ph.D., chief of the mucosal immunology unit in the laboratory of parasitic diseases at the National Institutes of Health

"If some set of microbes induces a specific immune response, this points to a way to manipulate the immune system," says Dr. Belkaid.

This new study is the first report that has associated a defined set of gut flora with the induction of specific immune cells," she added.

The study is published in the October 16 issue of the journal Cell Host and Microbe.

Source: ANI
RAS/SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sensory Processing Disorder (SPD)
First Dose of COVID-19 Vaccines May Improve Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Shigellosis Colo-rectal cancer - Management Crohns Disease Inflammatory Bowel Disease Foul Smelling Stool 

Recommended Reading
Scientists Identify Gene Behind Inflammatory Bowel Diseases in Kids
In a study of inflammatory bowel diseases in children like Crohn's disease and ulcerative colitis, ....
Scientists Identify Two New Genes Linked to Inflammatory Bowel Disease in Children
Researchers from Children's Hospital of Philadelphia have identified two genes that are responsible ...
Perceptions of Physicians and Patients Differ on the Impact of Colitis
A nationwide survey has revealed that almost three out of four patients with ulcerative colitis ......
Colo-rectal cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological t...
Crohns Disease
Crohn’s disease or regional enteritis is an inflammatory bowel disease that involves the small intes...
Foul Smelling Stool
Foul smelling stool is a stool that has a bad odor. Poor diet and indigestion are the most common ca...
Inflammatory Bowel Disease
Inflammatory bowel disease involves chronic inflammation of the colon and small intestine. Symptoms ...
Shigellosis
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use