About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Identify Gene Behind Inflammatory Bowel Diseases in Kids

by Rajashri on September 5, 2008 at 1:47 PM
Font : A-A+

 Scientists Identify Gene Behind Inflammatory Bowel Diseases in Kids

Scientists have identified a gene, called tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) that influences whether children get diseases like Crohn's disease early in life.

The findings of the study by an international team also points to a potential new target for treatment.

Advertisement

Co-first author of the study, Subra Kugathasan, MD, said that while scientists have earlier found several genes that influence susceptibility to the two diseases, this is the first to focus on inflammatory bowel disease (IBD) with childhood onset.

Kugathasan's future research will focus on discovery of additional IBD genes and in depth study of how these genes influence disease onset and progression.
Advertisement

"Our novel candidate gene is in the same inflammatory pathway as some other susceptibility genes, so it may represent an accessible target for treatment," Nature quoted Kugathasan, as saying.

Kugathasan said that both genetics and the environment have an effect on the risk of getting inflammatory bowel disease. If one identical twin suffers from Crohn's disease, the other has a 60 percent probability of getting it too.

However, he noted that the incidence of disease has drastically increased over the last half century. He also suggested a key role of the environment in disease development. Smoking is an environmental factor that is particular strong in increasing the risk of Crohn's disease.

"We have to conclude that the interactions between genetics and environment are responsible for most cases," he said.

The study compared the DNA of more than 1,000 children diagnosed with inflammatory bowel diseases at the average age of 11 with 4,250 controls (disease-free children), and confirmed the findings in a larger set of patients established by the British Wellcome Trust Case Control Consortium.

They used gene chip microarray technology to scan thousands of one-letter alternative genetic "spellings" -- known to geneticists as single nucleotide polymorphisms (SNPs)-- spread throughout the patients' DNA.

Most of the SNPs made little difference when it came to affecting the risk of inflammatory bowel disease, but a few stood out, and two had not been seen before.

One new SNP led the scientists to TNFRSF6B, whose activity they found was associated with the degree of inflammation in the colon. The function of the second SNP is still under investigation.

TNFRSF6B encodes a protein that lengthens the duration of an immune response by regulating the longevity of activated white blood cells.

Kugathasan said that a related protein, tumor necrosis factor alpha, is the target of an existing antibody treatment for inflammatory bowel disease. This suggests that antibodies to TNFRSF6B could also be helpful in controlling the disease, he says.

The study was published online by the journal Nature Genetics.

Source: ANI
RAS/M
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Height and Weight-Kids Colo-rectal cancer - Management Crohns Disease Inflammatory Bowel Disease Foul Smelling Stool 

Recommended Reading
Scientists Identify Two New Genes Linked to Inflammatory Bowel Disease in Children
Researchers from Children's Hospital of Philadelphia have identified two genes that are responsible ...
Anti-cancer Therapies may Be Derived from Marine Animals
A new study suggests that natural products derived from marine animals may have potential use in ......
'Good' Gut Bacteria Linked to Better Outcome in Inflammatory Bowel Disease
Scientists at the California Institute of Technology have found that a good bacterium in the gut ....
Colo-rectal cancer - Management
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological t...
Crohns Disease
Crohnís disease or regional enteritis is an inflammatory bowel disease that involves the small intes...
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Foul Smelling Stool
Foul smelling stool is a stool that has a bad odor. Poor diet and indigestion are the most common ca...
Inflammatory Bowel Disease
Inflammatory bowel disease involves chronic inflammation of the colon and small intestine. Symptoms ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)