Leptin action is not the culprit behind overeating, and leading to obesity, report the findings of a new research.
Assistant professor Diego Perez-Tilve, PhD, at the University of Cincinnati, said that restoring leptin action will not be effective at reducing obesity because leptin action is normal as opposed to being impaired in obesity.
Leptin is a hormone that plays a role in appetite and weight control. It is produced when we are well fed, and signals to the brain that there is ample energy and therefore reduces eating.
In the study, the team blocked leptin action in both lean and obese mice. The results were both sets of mice ate more and gained almost similar weight, proving that "leptin action was not impaired in the obese mouse."