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Impaired Action of Hunger Hormone Leptin May Not Be the Culprit Behind Obesity

by Julia Samuel on May 19, 2015 at 7:04 PM
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Impaired Action of Hunger Hormone Leptin May Not Be the Culprit Behind Obesity

Leptin action is not the culprit behind overeating, and leading to obesity, report the findings of a new research.

Assistant professor Diego Perez-Tilve, PhD, at the University of Cincinnati, said that restoring leptin action will not be effective at reducing obesity because leptin action is normal as opposed to being impaired in obesity.


Leptin is a hormone that plays a role in appetite and weight control. It is produced when we are well fed, and signals to the brain that there is ample energy and therefore reduces eating.

Perez-Tilve said the hormone has been of interest since 1994, when scientists discovered that a particular strain of obese mouse couldn't produce leptin at all, making it hungry all the time.

In the study, the team blocked leptin action in both lean and obese mice. The results were both sets of mice ate more and gained almost similar weight, proving that "leptin action was not impaired in the obese mouse."

Source: Medindia


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