About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Single-dose of COVID-19 Vaccine Stimulates Immunity in COVID-19 Survivors
Advertisement

Single-dose of COVID-19 Vaccine Stimulates Immunity in COVID-19 Survivors

Font : A-A+

Highlights:
  • COVID-19 survivors developed an antibody response after a single dose of Pfizer vaccine
  • The vaccine is usually administered in two doses, 21 days apart to provide full protection
  • Health officials say this could help speed up the vaccination process

A single dose of the Pfizer-BioNTech vaccine for COVID-19 survivors was found to generate an immunologic response similar to that of individuals receiving the two-dose recommended sequence, according to a Cedars-Sinai study published today by the journal Nature Medicine.

"Our findings extend those from smaller studies reported elsewhere and support a potential strategy of providing a single dose of vaccine to persons with a confirmed prior history of coronavirus infection, along with two doses for people not previously infected," said Susan Cheng, MD, MPH, MMSc, associate professor of Cardiology and director of Public Health Research at the Smidt Heart Institute at Cedars-Sinai. "This approach could maximize the reach of a limited vaccine supply, allowing potentially millions more people to be vaccinated in the U.S. alone."

Advertisement


The vaccine that was studied, produced by Pfizer Inc. and BioNTech SE, normally is administered in two doses, 21 days apart, to provide nearly full protection against the novel coronavirus, known as SARS-CoV-2.

"It appears that a single booster dose given to previously infected individuals offers the same benefit as two doses given to people without prior infection." Sobhani and Cheng, along with Jonathan Braun, MD, PhD, professor of Medicine at the F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute at Cedars-Sinai, co-senior-authored this study.
Advertisement

For their research, the investigators administered surveys to 1,090 healthcare workers in the Cedars-Sinai Health System who had received the Pfizer-BioNTech vaccine. The surveys asked the workers about prior coronavirus infections and any symptoms they might have experienced after being vaccinated.

The healthcare workers also took antibody tests to gauge the response of their immune systems to the vaccinations. Antibody levels were measured at three points in time: before or up to three days after the first dose, within seven to 21 days after the first dose, and within seven to 21 days after the second dose.

Based on the surveys, the research team identified 35 individuals with prior coronavirus infections who had received a single vaccine dose and 228 individuals without prior infection who had received both vaccine doses. Based on the antibody tests, the team found that levels and responses of coronavirus-specific antibodies were similar in both of these groups.

Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomatology was similar between the two groups after the second dose.

The investigators said their study had limitations and that more research will be needed to confidently guide vaccine policy.

They noted that they measured antibody levels only up to 21 days following each vaccine dose and that longer-term follow-up likely would provide additionally informative data, especially regarding the duration of the immunity acquired from receiving a single versus double dose of the vaccine.

They also noted that even larger cohort samples will be needed to examine differences across demographic and clinical subgroups that are known to exhibit variation in antibody response following vaccination. More studies also are needed to determine if the results seen after a single dose of the Pfizer-BioNTech vaccine might also apply to other SARS-CoV-2 vaccines, they added.

Source: Eurekalert

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Colleen Fleiss. (2021, April 03). Single-dose of COVID-19 Vaccine Stimulates Immunity in COVID-19 Survivors. Medindia. Retrieved on May 19, 2022 from https://www.medindia.net/news/healthwatch/single-dose-of-covid-19-vaccine-stimulates-immunity-in-covid-19-survivors-200650-1.htm.

  • MLA

    Colleen Fleiss. "Single-dose of COVID-19 Vaccine Stimulates Immunity in COVID-19 Survivors". Medindia. May 19, 2022. <https://www.medindia.net/news/healthwatch/single-dose-of-covid-19-vaccine-stimulates-immunity-in-covid-19-survivors-200650-1.htm>.

  • Chicago

    Colleen Fleiss. "Single-dose of COVID-19 Vaccine Stimulates Immunity in COVID-19 Survivors". Medindia. https://www.medindia.net/news/healthwatch/single-dose-of-covid-19-vaccine-stimulates-immunity-in-covid-19-survivors-200650-1.htm. (accessed May 19, 2022).

  • Harvard

    Colleen Fleiss. 2021. Single-dose of COVID-19 Vaccine Stimulates Immunity in COVID-19 Survivors. Medindia, viewed May 19, 2022, https://www.medindia.net/news/healthwatch/single-dose-of-covid-19-vaccine-stimulates-immunity-in-covid-19-survivors-200650-1.htm.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Prevent Hacking of Medical Devices: FDA Sounds Alarm
Black Water: Benefits and Uses
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Immunisation Myasthenia Gravis Blood Group Diet Vaccination for Children Boils - Treatment by Drugs Top 10 Vaccine Myths Debunked Coronavirus Indian Namaste the Preferred Greeting over Conventional Handshake COVID in Children COVID Vaccination for Pregnant Women 

Most Popular on Medindia

Drug Interaction Checker Iron Intake Calculator Blood Donation - Recipients Loram (2 mg) (Lorazepam) How to Reduce School Bag Weight - Simple Tips Sanatogen Nutam (400mg) (Piracetam) Color Blindness Calculator The Essence of Yoga Hearing Loss Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use