About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

New Compound With Better Outcomes To Treat Severe Malaria

Font : A-A+

Highlights
  • Severe malaria is a life-threatening condition that inevitably leads to the death if not treated immediately.
  • Malaria is currently treated with intravenous or intramuscular artesunate for at least 24 h or, if parenteral artesunate or artemether are not available, with i.v. Quinine.
  • SC81458 and SC83288, are fast-acting compounds that can cure a P. falciparum infection in a humanized mouse model system.

New Compound With Better Outcomes To Treat Severe Malaria

Severe malaria, caused by the Plasmodium falciparum parasite, causes dangerous circulatory disorders and neurological complications. If the affected person is not treated immediately, the disease will inevitably lead to death.

On the one hand, the currently used drugs artesunate and quinine have unwanted side effects and, on the other, more and more plasmodia are becoming resistant to them. Developing new drugs with other mechanisms of action is therefore essential.

Advertisement


Scientists from the Heidelberg University Hospital and the German Center for Infection Research (DZIF) have developed a new substance that has cured severe malaria in humanised mice.

"New drugs for treating severe malaria are indeed urgently needed," emphasizes Prof Michael Lanzer, DZIF scientist at the Heidelberg University Hospital.
Advertisement

In a DZIF project, he developed the first promising candidate together with his research team: SC83288, with a somewhat prosaic name has the required properties, and has already been successfully used to treat severe malaria in humanised mice.

The starting point of the drug development was benzamidine derivatives, which had been effective against different parasites in veterinary medicine but were not used as they have severe side effects.

The scientists have now tried to modify these substances so that they become suitable to treat severe malaria. The substance was chemically modified to make it more tolerable without forfeiting its effect against parasites.

"The new chemical structure is very well tolerated, is metabolised rapidly in the body and the crucial factor: in animal models, it can kill the severe malaria parasites in a short period of time," explains Lanzer.

For their tests, the scientists used mice with human blood cells and that had been infected with severe malaria. In this model system, SC83288 was effective in the late stages of malaria, during which the parasites are in the blood cells where they cause severe damage. Detailed preclinical studies on pharmacokinetics and toxicology showed consistent positive results for the substance which is to be administered intravenously.

"We are now in the process of conducting the regulatory preclinical procedures and hope to initiate the clinical trials in 2018," says Lanzer.

Reference
  1. stefanao Pegoraro et al., SC83288 is a clinical development candidate for the treatment of severe malaria, Nature Communications (2017) doi:10.1038/ncomms14193.


Source: Medindia

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Malaria-water Malaria Mosquito Diseases Fever Malaria - Protection Strategies 

Most Popular on Medindia

Post-Nasal Drip Pregnancy Confirmation Calculator Noscaphene (Noscapine) Accident and Trauma Care A-Z Drug Brands in India Sanatogen Find a Hospital Blood Pressure Calculator How to Reduce School Bag Weight - Simple Tips Nutam (400mg) (Piracetam)
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

New Compound With Better Outcomes To Treat Severe Malaria Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests