About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Statins and Anti-Stroke Drug Combinations May Increase Bleeding Risk
Advertisement

Statins and Anti-Stroke Drug Combinations May Increase Bleeding Risk

Font : A-A+

Highlights
  • Dabigatran is an oral anticoagulant prescribed in atrial fibrillation (AF) patients to reduce risk of stroke, with similar efficacy to warfarin, another popular oral anticoagulant.
  • Dabigatran is preferred over warfarin since it carries lesser risk of major life threatening bleeds when compared to warfarin.
  • Simvastatin and Lovastatin are two commonly used ‘statins’ to reduce levels of LDL or bad cholesterol and triglycerides.
  • Recent studies have shown that the risk of hemorrhage is much higher if either Simvastatin or Lovastatin, is given to patients taking dabigatran.

Two commonly prescribed 'statins', Simvastatin and Lovastatin , used to lower levels of LDL cholesterol and triglycerides for prevention of heart disease, have been shown to cause increased incidence of bleeding when given to patients on dabigatran , a drug prescribed to prevent stroke in atrial fibrillation patients, according to a recent study in Ontario, Canada.

Advertisement


Aim of the Study
Atrial fibrillation and high lipid levels are both independently associated with a higher risk of stroke and heart disease, and can occur in the same patient. Consequently dabigatran and statins might be prescribed together for treatment.

The study, conducted in Canada aimed to determine any adverse drug interactions that could occur between statins (lipid lowering agents) and dabigatran, a direct acting anticoagulant, prescribed in patients with AF.
Advertisement

Interestingly, studies conducted earlier have detected significant drug-drug interactions between warfarin (another oral anticoagulant) and statins, potentiating the anticoagulant effect of warfarin.

Details and Findings of the Study

Two separate studies were conducted on the residents of Ontario, aged 65 years and above who were started on dabigatran between 2012 and 2014, and involved a total of 45,991 patients. The findings of the study were as follows

  • 397 patients suffered a stroke and 1117 persons had a major hemorrhage.
  • The risk of bleeding increased by over 40 percent in patients who also took Simvastatin or Lovastatin, in comparison to those who were on other statins.
  • "An increase in the risk of bleeding requiring hospital admission or emergency department visits was seen with lovastatin and simvastatin compared with the other statins," Dr. Antoniou said.
  • The stroke risk of both Simvastatin and Lovastatin was similar in patients taking dabigatran.
"We found no difference in the risk of stroke in patients receiving dabigatran who were prescribed lovastatin or simvastatin versus other statins," said Dr. Tony Antoniou, a pharmacist at St. Michael's Hospital and researcher in its La Ka Shing Knowledge Institute and an adjunct scientist at the Institute for Clinical Evaluative Sciences.

Possible Mechanism of Interaction Between Statins and Dabigatran

Simvastatin and Lovastatin are thought to enhance dabigatran absorption by the body, causing increased blood levels, potentiating its anticoagulant effect and increasing risk of hemorrhage. This effect is not observed with other statins such as Atorvastatin .

Lessons from the Study

The findings of the study indicate that a potentially harmful and clinically significant drug interaction occurs between dabigatran and Simvastatin/Lovastatin. In patients with atrial fibrillation on dabigatran, alternative statins such as Atorvastatin should be considered instead of Simvastatin or Lovastatin.

Source: Medindia

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol Drug Toxicity Signature Drug Toxicity Cholesterol - The Enigma Chemical Statins von Willebrand Disease Drugs Banned in India Hemophilia 

Most Popular on Medindia

Sanatogen Drug Side Effects Calculator A-Z Drug Brands in India Turmeric Powder - Health Benefits, Uses & Side Effects Noscaphene (Noscapine) Drug - Food Interactions Indian Medical Journals Hearing Loss Calculator Iron Intake Calculator Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Statins and Anti-Stroke Drug Combinations May Increase Bleeding Risk Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests