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Simvastatin - Indications, Dosage, Side Effects and Precautions

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Information about Simvastatin

Generic Name : Simvastatin
Up-to-date prescription details regarding Simvastatin are provided here.
Pronunciation : SIM-va-STAT-in
Learn the correct pronunciation of the Simvastatin, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.
You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.
ICD Code : Y52.6 | Therapeutic Classification : Antilipemics
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Trade Names/Brand Names of Simvastatin

India : 

More...

International : 

Zocor
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Why is Simvastatin Prescribed? (Indications)

This medication is an HMG-CoA reductase inhibitor, also known as a "statin", used for lowering high cholesterol and triglycerides in certain patients with appropriate diet. It reduces the risk of cardio vascular diseases, and blood vessels blockage. 

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When should Simvastatin not be taken? (Contraindications)

Contraindicated in patients with hypersensitivity, acute liver disease or unexplained persistent elevations of serum transaminases, during pregnancy and breastfeeding.

What is the dosage of Simvastatin?

The recommended dose is 5-20mg/day by orally. The maximum dose is 40mg/day.

How should Simvastatin be taken?

It comes as a tablet to take by mouth (orally). It is usually taken one to three times a day, with or without food. Avoid excessive consumption (> 1 L/day) of grapefruit juice.

What are the warnings and precautions for Simvastatin?

• Caution should be exercised patients with history of liver disease.

• It may lead to rapid breakdown of skeletal muscle (rhabdomyolysis), severe infection, low blood pressure, major surgical trauma, uncontrolled seizures or severe metabolic, endocrine and electrolyte disorder.

• Avoid drinking alcohol otherwise it may result in liver failure.

• This medication should be used with extreme caution in children younger than 10 years old and in those who have not reached puberty. Discontinue treatment if there is marked or persistent increase in serum-aminotransferase concentrations.

What are the side effects of Simvastatin?

  Central Nervous System: Headache, dizziness, sleeplessness, depression.
  Gastrointestinal: Nausea, flatulence, distortion of the sense of taste, abdominal pain, diarrhea, constipation.
  Eye: Lens opacities, blurring of vision.
  Metabolic: Serum transaminases and CPK elevations.
  Musculoskeletal: Muscle pain, muscle weakness and Immune-Mediated Necrotizing Myopathy (IMNM).
  Miscellaneous: Heartburn, hypersensitivity, sexual dysfunction, and upper respiratory symptoms.

What are the other precautions for Simvastatin?

Avoid changing the dose without doctor's advice.

What are the storage conditions for Simvastatin?

Oral: Store at 5-30°C. Store it in an airtight container and keep away from children.

Last Updated : August 11, 2022
Learn more about Simvastatin's interaction with Food, Herbs and Alcohol



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  • 1. Simvastatin - (https://medlineplus.gov/druginfo/meds/a692030.html )
  • 2. Pregnancy outcomes after maternal exposure to simvastatin and lovastatin - (https://pubmed.ncbi.nlm.nih.gov/16163683/ )
  • 3. Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin - (https://pubmed.ncbi.nlm.nih.gov/15206993/ )
  • 4. Taking simvastatin in the morning compared with in the evening: randomised controlled trial - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC214096/ )
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Barb1340, United States

Is this medication gluten free

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