- The Cell and Gene
Medicine laboratory at Stanford University is considered to be the most
state of the art facility.
- New research has
shown that gene-engineered skin cells could be used to treat genetic skin
- Upcoming projects
could revolutionize medicine and treatment options
Cell and Gene Medicine laboratory at
Stanford University has recently been a hub of activity as researchers have
Identified that are capable of
treating cancer, blood disease, patch your heart, improve the immune system or
alter it, grow grafts of skin with many more possible line of therapies.
laboratory is a large facility with 25,000 square feet of space and which
opened last September. However, the discoveries that have since been
established have successfully made Stanford the forerunner of Medicine. The
current studies that focus on regenerative medicine and which seek to repair
damaged or infected cells using the body's own healthy cells has been a
significant stride in the pursuit of promising research trends.
‘Gene-engineered skin cells manufactured in the Cell and Gene Medicine lab at Stanford University may help treat genetic skin disorders.’
David DiGiusto who is the Director of this laboratory said "We're curing
Silicon Valley in the U.S has always been talked about its innovative steps in
the field of technology but critics have long been stating that there have been
only technological advancements but seldom to do with medicine.
new research that aided in the development of gene-engineered cells has brought
in much needed appreciation for the automated biological manufacturing
laboratory which could be the future of regenerative medicine.
Discovery from the Laboratory
research team from the laboratory successfully developed genetically corrected
skin as small sheets and which was grafted into patients who suffered from a
disease called epidermolysis
Bullosa, a blistering skin disease. This is a painful genetic condition in
which a protein called type-7 is improperly synthesized, leading to a condition
where the layers of the skin do not adhere properly. In order to correct this
genetic condition, viruses are used to incorporate the correct variant of the
gene into skin cells and then inducing the production of sheets of skin.
University is not looking at commercializing the products just yet but will be
using the products for clinical trials
projects that the laboratory hopes to focus on include:
- T cells that are
genetically engineered to fight cancer cells.
- Repairing damaged
tissue of the heart by inducing cardiac cells
problems with the eye by regenerating corneal cells
- Treating sickle cell anemia as well as beta
thalassemia by repairing mutations present in a single gene of red
rejection of transplanted bone marrow by disabling immune cells
Stanford University run laboratory could partner with a new company or partner
with other leading institutions for further medical advancements. In order to ship its products across the
state, the laboratory is aiming to get to get a license as a biological
Ruffin who is the Managing Director for the non-profit Washington D.C based
company Alliance for Regenerative Medicine,
said, "Manufacturing facilities like this are vital to moving this
sector forward helping to speed the translation of crucial gene and cell
therapies to reach patients with currently unmet medical needs."
for Regenerative Medicine advocates research and
commercialization of therapies to renew and regenerate tissues and organs.
have been other research labs like the City of Hope at Los Angeles, University
of Washington's MD Anderson Cancer Center, and University of Pennsylvania which
have expressed an intention to work with this laboratory to take medical
Director of the laboratory, Di-Gusto adds that the upcoming projects at the
laboratory are unique and will pioneer medical research. There is no facility
as large and as state of the art as this laboratory, which could be the envy of
many pharma giants, according to the Director.
lab has already become highly in demand and exciting projects have now been
waitlisted as there are too many. It would be exciting to wait and find out
what will be new from this
lab and how it will affect the treatment of diseases.
skin sheets that were developed in this laboratory will not only be useful in
the treatment of the genetic disease condition but could also be used on burn
victims who lack the necessary skin. Stanford University has always been one of
the leading institutions of research in all fields which includes medicine,
however, this laboratory could bring into focus medical research in an
environment where developing Apps and gadgets has been the mainstay. Silicon
Valley will have something new to boast about.
- Stanford Lab Working To 'Cure The Incurable' - (http://californiahealthline.org/morning-breakout/stanford-lab-working-to-cure-the-incurable/)