- Astronomical techniques can now be applied for the diagnosis and treatment of cancer
- These techniques are helping to develop rapid diagnostic tests (RDTs) and effective treatments for cancer
- Photodynamic and photothermal therapies are emerging as effective treatment regimens for breast cancer and non-melanoma skin cancer (NMSC)
The study was jointly led by Dr. Charlie Jeynes, PhD and Professor Tim Harries, PhD. Dr. Jeynes is an STFC ‘Innovation’ Research Fellow at the Center for Biomedical Modeling and Analysis, University of Exeter, UK. Professor Harries is the Head of Physics and Astronomy at the University of Exeter, UK.
The work is being presented by Jeynes at the Royal Astronomical Society’s National Astronomy Meeting (NAM 2019) at the University of Lancaster, UK.
Breast Cancer Facts
- 60,000 new breast cancer cases are reported every year in the UK
- 12,000 of these women die from the cancer
- Early diagnosis of breast cancer significantly increases the chances of survival
- 90 percent of women diagnosed at an early stage survive for at least 5 years
- 15 percent of women diagnosed at an advanced stage survive for 5 years
How is Breast Cancer Linked to Astronomy?During the development of breast cancer, calcium is deposited in the breast tissues. The calcium deposits have a higher density compared to the surrounding tissue. This difference in density can be detected by a shift in the wavelength of light during its passage through the breast tissue. These same principles have been used for a long time in astronomy for studying the formation of planets and stars. Hence, breast cancer detection and astronomy are linked through the same technology used in both disciplines.
Jeynes says: “Light is fundamental to a diverse range of medical advances, like measuring blood oxygenation in premature babies, or treating port-wine stains with lasers. So there is a natural connection with astronomy, and we’re delighted to use our work to take on cancer.”
What Studies are Being Conducted by Astronomers on Cancer?The major studies being carried out at the University of Exeter are briefly highlighted below:
- Computer modeling is being used to elucidate the behavior of light waves when they pass through human tissue, which will eventually help to develop rapid diagnostic tests (RDT), alleviating the need for biopsies
- Computer modeling is being used for developing new treatments for non-melanoma skin cancer (NMSC), which is the most common type of skin cancer, affecting 80,000 people annually in England
- A simulated ‘virtual laboratory’ is being developed based on computer coding to study skin cancer treatments
- The new treatments for skin cancer involve light-activated drugs for photodynamic therapy and light-heated nanoparticles for photothermal therapy
- The new treatments are effective in rats and will soon be tested in humans
Future PlansThe research team plans to carry out three-dimensional (3-D) modeling using actual images of tumors, so that they can simulate the effect of different treatment modalities. The efficacy of these treatments under simulation will be compared to actual data on how the tumors respond to treatment. This will help in predicting which treatment regimen is the best for a particular type of tumor, thereby giving doctors a variety of options to choose from while planning treatment.
Concluding RemarksJeynes concludes: “Advances in fundamental science should never be seen in isolation. Astronomy is no exception, and though impossible to predict at the outset, its discoveries and techniques often benefit society. Our work is a great example of that, and I’m really proud that we’re helping our medical colleagues wage war on cancer.”
- Applying an Astrophysics Modeling Tool to Improve the Diagnosis and Treatment of Cancers Using Theranostic Nanoparticles - (https://www.nam2019.org/wednesday/details/22/21)