Glutathione S-transferase mu-1 (GSTM1) is an enzyme that plays a role in ridding the body of toxins and combatting oxidative stress. Many individuals carry a variant in the GSTM1 gene that prevents the gene's expression (called a null variant) and therefore they lack production of the enzyme. A team led by Thu H. Le, MD (University of Rochester Medical Center) previously showed that individuals carrying this variant face a higher risk of experiencing kidney function decline.
"We speculate that the GSTM1 enzyme may be involved in the breakdown of antioxidant-promoting compounds, and therefore deficiency in the enzyme may increase the bioavailability of protective compounds relevant in kidney disease," said Dr. Le.
When the researchers examined information from a large clinical trial, they found that high consumption of broccoli and other cruciferous vegetables was linked with a lower risk of kidney failure, primarily in participants with the GSTM1 null variant.
"Our study highlights diet-gene interactions in kidney disease and illustrates that response to the disease-modifying effect of diet is influenced by genetics," said Dr. Le. "In the context of personalized and precision medicine, increased consumption of cruciferous vegetables may be protective, particularly in those lacking GSTM1 who are genetically most at risk for kidney disease progression.
Furthermore, our study suggests that knowing an individual's genetic information enables tailoring an intervention to prevent or delay kidney disease progression among those who would respond based on their genetic makeup."