About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Effectiveness of HIV Vaccine Influenced by Individual Genotype

by Kathy Jones on August 9, 2014 at 11:13 PM
 Effectiveness of HIV Vaccine Influenced by Individual Genotype

Official statistics indicate that almost 40 million people worldwide live with HIV/AIDS.

Despite great effort, HIV-1 vaccine development has been challenging. A recent HIV vaccine trial, known as RV144, revealed that a combination of 2 vaccines protected some individuals from HIV infection.

Advertisement

Individuals in the trial that made antibodies that bound to a specific region of the HIV envelope protein had a decreased risk of HIV infection. A new study in the Journal of Clinical Investigation reveals that an individual's genotype correlates with their ability to develop immunity to HIV in response to vaccination. Sue Li and colleagues at the Fred Hutchinson Cancer Research Center sequenced genes in RV144 participants that are involved in antibody production. The authors identified single nucleotide variations in genes that encode antibody receptors, which are important for protective immunity. They found that the majority of individuals with specific variants of the FCGR2C gene were protected from HIV infection after vaccination whereas a different form of FCGR2C was not associated with protection. Their study provides important insight into the variable response of individuals in the RV144 trial.



Source: Eurekalert
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest AIDS/HIV News

HIV Vaccine Clinical Trial Initiates in the United States and South Africa
The Phase 1 trial for a preventive HIV vaccine candidate has initiated enrollment in both the United States and South Africa.
Beauty Salon-Driven Initiative Boosts PrEP Awareness in Fight Against AIDS
In the United States, African American women make up only 26% of female PrEP users, yet they account for 57% of new infections among women.
Immune-Evading HIV Protein Complex Solved
Scientists have made a groundbreaking discovery in the fight against HIV/AIDS with the successful resolution of the enigmatic immune-evading HIV protein complex.
Does Gender Influence Comorbidity Rates in HIV-Positive Smokers
Tailored quit-smoking programs are designed to address the risks associated with comorbidity in individuals living with HIV.
Digital Test Measures HIV Viral Load
DNA editing tool CRISPR-Cas13 helps diagnose and signal the presence of HIV antibodies in HIV patients.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Effectiveness of HIV Vaccine Influenced by Individual Genotype Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests