Medindia
Advertisement

DNA-based Nanomachines Help Fight Cancer

by Colleen Fleiss on February 9, 2019 at 8:17 PM

DNA-based Nanomachines Help Fight Cancer
New DNA-based nanomachines that can be used for gene therapy of cancer have been proposed by scientists from ITMO in collaboration with their international colleagues. This new invention can greatly contribute to making the treatment of oncological diseases more effective and selective. The results were published in Angewandte Chemie.

Gene therapy is considered one of the promising ways of treating oncological diseases, even though the current approaches are far from perfect. Oftentimes, the agents fail to discern malignant cells from healthy ones, and are bad at interacting with folded RNA targets. In order to solve this issue, scientists, including a Russian team from ITMO University headed by professor Dmitry Kolpashchikov, proposed special nanomachines. Their operation principle is based on using particular molecules, deoxyribozymes, which can interact with targeted RNA, bind them, unfold and cleave.
Advertisement


The researchers have tested the efficiency of the new machines in a model experiment and learned that they can cleave folded RNA molecules better than the original deoxyribozymes. They showed that the design of the nanomachine makes it possible to break down targeted RNA in the presence of a DNA oncomarker only, and the use of RNA-unfolding arms provides for the machine's better efficiency. The scientists also learned that the nanomachine can inhibit the growth of malignant cells, though cellular experiments didn't show high specificity. The researchers associate such a result with a possibly poor choice of the RNA target and a low stability of DNA structures in the cell.

The new approach differs fundamentally from the ones used before. The existing gene therapy agents are aimed at suppressing the expression of oncological markers. In the research in question, the scientists focused on the messenger RNA of vital genes, and the oncological marker was used as an activator. This makes it possible to apply the DNA nanomachine in treating any kind of cancer by using new DNA oncomarkers for activating the breaking down of targeted molecules.
Advertisement

The new invention opens new ways of treating oncological diseases. Still, there are many experiments to be conducted before it can be applied in therapy.

"For now, we are trying to introduce new functional elements in the framework, ones that will contribute to a more effective recognition of oncological markers, and are also optimizing the DNA nanomachine for various RNA targets. In order to improve the efficiency and selectiveness of our constructions in cellular conditions, we are selecting new RNA targets and studying the stability of DNA machines in cells, which we plan to improve with the help of the already existing chemical modifications," comments Daria Nedorezova, Master's student at ITMO University.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
Lower Respiratory Tract Infections Linked to Obstructive Sleep Apnea in Children
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Benefits of a Vegan Diet for Fighting Cancer Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

Recommended Reading
Cancer Must Know Facts
A list of Must Know Top 12 Cancer Facts of the World....
Quiz on Cancer
Cancer, is the second most leading cause of death worldwide. Cancer is not just one disease but ......
Lifetime Risk Calculator for Cancers
What are your chances for developing some common cancers in your lifetime - find out now....
Cancer Prevention thro' Lifestyle Changes
Did u know that simple changes in lifestyle could lower your cancer risks? Find out how!...
Benefits of a Vegan Diet for Fighting Cancer
A vegan diet consisting of fruits, vegetables and other plant-based food sources has been shown to h...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use