Cranberries can offer new hope in the fight against urinary tract infections (UTIs), reports a new study.
Many people have heard that drinking cranberry juice can help prevent urinary tract infections (UTIs). Although clinical trials of this popular folk remedy have produced mixed results, some studies have shown that drinking cranberry juice can keep bacteria that cause UTIs from sticking to cells lining the urinary tract.
Now, researchers reporting in ACS' Journal of Natural Products have identified cranberry oligosaccharides in the urine of cranberry-fed pigs that could be responsible for this activity.
The research team fed female pigs dried cranberry powder, collected their urine and used chromatography to separate it into fractions of differently sized molecules. Then, they screened the samples for anti-adhesion activity against the E. coli bacteria that cause UTIs.
To the researchers' surprise, proanthocyanidins, the compounds previously proposed to be responsible for cranberry's apparent UTI prevention properties, were absent from the active urine fractions. Instead, the researchers detected oligosaccharides called arabinoxyloglucans in those samples. These complex carbohydrates, related to cellulose, are difficult to detect and isolate, which could explain why they hadn't previously been identified as anti-adhesive components of cranberry, the researchers say.