Common Virus in Early Childhood Could Be a Culprit Behind Celiac Disease

This preliminary finding adds new information on the role of viral infections as a potential underlying cause of celiac disease, say the researchers.

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Celiac disease is a common digestive condition caused by an adverse reaction to gluten, a dietary protein found in wheat, barley and rye. It is believed to develop from a combination of genetics and environmental triggers.

Previous studies suggest that stomach and intestinal infections, which are common in childhood, play a role in the development of celiac disease. But no firm conclusions have been made.

So researchers tested whether enterovirus and adenovirus infections - before the development of celiac disease antibodies - were more common in children who were later diagnosed with celiac disease, compared to those who were not.

Between 2001-2007, they recruited 220 Norwegian children who all carried both the HLA DQ2 and the DQ8 genetic makeup. The large majority of patients with celiac disease carry at least one of these, which carries an increased risk of both celiac disease and type 1 diabetes.

The researchers collected stool samples from age 3 - 36 months to detect the viruses, and blood samples were tested for celiac disease antibodies at age 3, 6, 9 and 12 months, and then yearly until 2016.

After an average of nearly 10 years, 25 children were diagnosed with celiac disease. Each child was then matched to two healthy controls.

Enterovirus was found in 370 (17%) of 2135 stool samples, with 73 children having at least one positive sample. And it was significantly more frequent in samples collected before development of celiac disease antibodies in cases than in controls - 84 out of 429 (20%) in cases and 129 out of 855 (15%) in controls.

There was a significant association between exposure to enterovirus and later risk of developing celiac disease, but adenovirus was not linked to the development of the disease.

Enterovirus infections caught after gluten was introduced to the child's diet were associated with celiac disease, whereas those before or at the time of introduction were not, suggesting that the infection itself was the disease trigger.

This is an observational study, therefore no firm conclusions can be made about cause and the researchers can't rule out the possibility that other unmeasured factors may have influenced the results. What's more, the number of children with celiac disease was limited and the findings may not be generalized to wider genetic profiles.

But the authors point out that this is the first study of its kind to explore the link between viruses in childhood and later celiac disease.

And the HLA-DQ2 or HLA-DQ8 gene makeup represents nearly all "genetically susceptible" people, therefore they believe that their findings are likely to apply to a large proportion of those with celiac disease.

With almost 40 percent of the population being genetically prone to coeliac disease, the authors highlight the "major problem" of identifying environmental triggers.

The authors suggest that identifying specific viruses as triggers may justify preventative strategies: "If enterovirus is confirmed as a trigger factor, vaccination could reduce the risk of development of celiac disease," they conclude.

Source: Eurekalert