Break Obesity-driven Liver Damage With Targeted Therapy

The mainstay of treatment for non-alcoholic fatty liver disease (NAFLD) like diet programs, exercise regimens, medications and bariatric surgery to lose weight were not enough to stop develop progressive NAFLD.

Reports by 20 scientists at Cincinnati Children's on studying the numerous mechanisms involved with obesity and NAFLD paved way for progressive treatment approach. the findings of the study were published in the journal Cell Metabolism.

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‘Control obesity-driven liver damage with modulated immune response.’

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The researchers conducted a series of experiments using human tissues and cells and multiple lines of genetically modified mice to find that abnormal immune activity due to excess fat deposition in liver attracts more ihTh17 cells to the liver that trigger inflammation to cause liver damage.

"Our results demonstrate for the first time that ihTh17 cells represent an important component of the complex world of NAFLD pathogenesis," say corresponding author Senad Divanovic, PhD, a member of the Division of Immunobiology at Cincinnati and first author Maria Moreno-Fernandez, PhD, a postdoctoral fellow in the Divanovic laboratory.

Regulating the ihTh17 cells’ function and their interaction with the liver cells and the immune system will break the abnormal pathway and lead to new therapies to reduce the liver damage.

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The study also confirms the detection of key genes and molecular activities occurring in the mice also in the human liver cells.This promising lead in the experiment needs to be explored in a targeted way to reduce the liver damage and provide better survival in obesity induced liver damage.

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