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Antibiotics and Disinfectant Use may Spread Multi-drug Resistant MRSA

by Rishika Gupta on September 23, 2017 at 3:42 PM
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Antibiotics and Disinfectant Use may Spread Multi-drug Resistant MRSA

Antibiotic usage among the household members and the influence of suspicious external environment carriers can be associated with the development of multi-drug resistance in Methicillin-Resistant Staphylococcus aureus (MRSA). This research was published in Applied and Environmental microbiology, a journal of the American Society for Microbiology.

Multi-drug resistance to MRSA and reinfection with MRSA, said corresponding author Jonathan Shahbazian, MPH, were the most important in the study, which also showed us that when used in humans or pets, the antibiotic Clindamycin was not associated with the risk of multi-drug resistant bacteria in the home.

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Treatment with Mupirocin, an antibiotic used to treat skin infections and to prevent the nasal spread of MRSA from sneezes, is weakly associated with Mupirocin resistance in the household environment. That "could complicate decolonization efforts that rely on the use of nasal mupirocin ointment," said Mr. Shahbazian, who conducted the study while finishing his masters in public health at Johns Hopkins Bloomberg School of Public Health, Baltimore. ("Decolonization" refers to treatment to eradicate potentially disease-causing bacteria from human carriers.)

Additionally, Mr. Shahbazian said that 100 percent of MRSA isolates the investigators obtained from rural homes were multi-drug resistant, "suggesting living in a rural household may be a risk factor for multi-drug resistance.
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"We also found the presence of domestic pets was associated with multi-drug resistant MRSA in the home environment, while the presence of unwanted pests, such as mice or cockroaches, was associated with non-multi-drug resistant MRSA strains," said Mr. Shahbazian.

In the study, the investigators collected samples from the home environments and pets of households enrolled in a large randomized controlled trial, which took place over a 14 month period. They tested whether household-wide efforts to eradicate MRSA -- which included daily use of nasal mupirocin ointment and chlorhexidine body wash--were successful in reducing recurrence of MRSA among adults and children who had previously been diagnosed with a MRSA skin or soft tissue infection. They repeated sampling in 65 homes three months after the residents had been treated for MRSA, or, as a control, after they had been educated about MRSA.

"Based on the evidence, we strongly suspect that environmental contamination of the home with MRSA contributes to recurrence," said Mr. Shahbazian. The investigators also suspect that household-wide selective pressures on the home environmental reservoir of MRSA promote persistence of multi-drug resistant strains. "We hypothesize that infected or colonized people and companion animals shed MRSA into the home environment," which then re-infect household members.

The investigators concluded that a better understanding of what causes home environmental MRSA to become multidrug resistant, and thus harder to treat, could help in identifying which households are more likely to harbor multi-drug resistant MRSA so that these could be targeted for destroying the pathogen.

The investigators are involved in One Health research. One Health examines health problems from a multidisciplinary perspective that includes physicians, veterinarians, environmental experts, and others.



Source: Eurekalert
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